CAJ | 학술논문

目的:比较心房颤动合并经皮冠状动脉介入治疗(PCI)术后采用二联抗栓方案(华法林+氯吡格雷)(DT)和3 个月的三联抗栓方案(华法林+阿司匹林+氯吡格雷)(TT)+9 个月的二联抗栓方案(华法林+氯吡格雷,DT)(TT+DT)的有效性和安全性. 方法:入选心房颤动合并 PCI 术后病例 90 例,随机分为DT组(45例)和TT+DT组(45例). DT组采用12个月的二联抗栓方案,TT+DT组采用3个月的三联抗栓+9个月的二联抗栓方案. 对两组的有效性及安全性进行随访. 结果:有效性随访结果表明:TT+DT组心肌梗死、靶血管血运重建、卒中及支架内血栓形成事件低于 DT 组(P<0.05). 安全性随访结果表明:TT+DT组出血事件高于DT组,但无统计学差异(P>0.05). 结论:心房颤动合并PCI 术后采用TT+DT方案和DT方案在出血事件的安全性方面无显著差异,但TT+DT方案组治疗有效性优于DT方案组.
목적:비교심방전동합병경피관상동맥개입치료(PCI)술후채용이련항전방안(화법림+록필격뢰)(DT)화3 개월적삼련항전방안(화법림+아사필림+록필격뢰)(TT)+9 개월적이련항전방안(화법림+록필격뢰,DT)(TT+DT)적유효성화안전성. 방법:입선심방전동합병 PCI 술후병례 90 례,수궤분위DT조(45례)화TT+DT조(45례). DT조채용12개월적이련항전방안,TT+DT조채용3개월적삼련항전+9개월적이련항전방안. 대량조적유효성급안전성진행수방. 결과:유효성수방결과표명:TT+DT조심기경사、파혈관혈운중건、졸중급지가내혈전형성사건저우 DT 조(P<0.05). 안전성수방결과표명:TT+DT조출혈사건고우DT조,단무통계학차이(P>0.05). 결론:심방전동합병PCI 술후채용TT+DT방안화DT방안재출혈사건적안전성방면무현저차이,단TT+DT방안조치료유효성우우DT방안조.
Objective To compare the efficacy and safety of singular double antithrombotie therapy (DT) using warfarin plus clopidogrel and the combined antithrombotie therapy of 3-month triple antithrombotie therapy (TT) using warfarin, aspirinand clopidogrel and 9-month double antithrombotie therapy (DT) for the patients with atrial fibrillation undergoing PCI. Methods Ninety patients with atrial fibrillation undergoing PCI were randomly divided into two groups evenly: one group was treated with dual antithrombotic therapy group (DT) and the other group with the combined therapy, e. g. 3-month triple antithrombotie therapy (TT) and 9-month double antithrombotie therapy (DT + TT for short). All patients were followed-up by 12 months. The two groups were compared in terms of incidences of death , myocardial infarction , stroke , target-vessel revascularisation , stent thrombosis and bleeding adverse events. Results The incidences of myocardial infarction, stroke, target-vessel revascularisation , stent thrombosis and bleeding adverse events in the TT + DT group were all significantly lower than the DT group (P < 0.05). The follow-up on the safety indicated that the rate of bleeding in the TT +DT group was insignificantly higher than the DT group (P > 0.05). Conclusion There is no significant difference in safety between the two groups. However, the therapy of TT + DT is more effective.