CAJ | 학술논문

目的:探讨肝细胞生长因子及其受体 c-Met 的表达及临床病理因素与胃癌肝转移的关系.方法:应用免疫组化方法检测 HGF 和及其受体 c-Met 在胃癌和肝转移癌组织中的表达情况, 通过对比两者在原发癌和肝转移癌组织中的不同表达状态, 探讨二者及临床病理因素与胃癌肝转移发生的关系. 结果:实验组与对照组胃癌组织中 HGF 呈阳性表达率分别为 68%和 60%,两组比较差异具有统计学意义.实验组与对照组胃癌组织中c-Met 呈阳性表达率分别为86%和68%,两组比较差异具有统计学意义.胃癌患者的淋巴结转移、HGF 表达、c-Met 表达与胃癌肝转移有关;而浸润深度、分化程度与胃癌肝转移无关.原发癌和肝转移癌HGF表达一致性分析存在显著差异. 原发癌和肝转移癌c-Met表达一致性分析无显著差异. 结论:HGF 和c-Met 的高表达与胃癌肝转移机制有关,对于 c-Met 表达程度的评估可能成为预测胃癌肝转移有价值的预后指标.
목적:탐토간세포생장인자급기수체 c-Met 적표체급림상병리인소여위암간전이적관계.방법:응용면역조화방법검측 HGF 화급기수체 c-Met 재위암화간전이암조직중적표체정황, 통과대비량자재원발암화간전이암조직중적불동표체상태, 탐토이자급림상병리인소여위암간전이발생적관계. 결과:실험조여대조조위암조직중 HGF 정양성표체솔분별위 68%화 60%,량조비교차이구유통계학의의.실험조여대조조위암조직중c-Met 정양성표체솔분별위86%화68%,량조비교차이구유통계학의의.위암환자적림파결전이、HGF 표체、c-Met 표체여위암간전이유관;이침윤심도、분화정도여위암간전이무관.원발암화간전이암HGF표체일치성분석존재현저차이. 원발암화간전이암c-Met표체일치성분석무현저차이. 결론:HGF 화c-Met 적고표체여위암간전이궤제유관,대우 c-Met 표체정도적평고가능성위예측위암간전이유개치적예후지표.
Objective To investigate the relationships of HGF , c-Met expression and clinicopathological factors with liver metastasis of gastric cancer. Methods The tissues of primary tumors and corresponding liver metastasis were collected to detect the expression of HGF and c-Met by immunohistochemistry. Results The positive rates of HGF in the experimental group and the control group were 68% and 60%, respectively , with significant differences between two groups. The positive rates of c-Met of the two groups were 86% and 68%, respectively, with a significant difference between two groups. Lymph node metastasis, high expression of HGF and c-Met were significantly associated with liver metastasis of gastric cancer. The depth of invasion of bowel wall and degree of differentiation were not associated with the liver metastasis of gastric cancer. Conclusion High expressions of HGF and c-Met are closely associated with the liver metastasis mechanism of gastric cancer. The c-Met might be a useful indicator of liver metastasis in patients with gastric cancer.