四川医学
四川醫學
사천의학
Sichuan Medical Journal
2015年
8期
1149-1152
,共4页
HCV%心血管疾病%炎症指标%D二聚体
HCV%心血管疾病%炎癥指標%D二聚體
HCV%심혈관질병%염증지표%D이취체
HCV%cardiovascular disease%inflammation indicator%D dimer
目的 分析持续感染HCV患者中心血管疾病( cardivascular disease, CVD)的发病与血清学炎症因子表达水平的相关性,探讨HCV感染患者中CVD发病可能的相关因素. 方法 分析HCV-DNA( +)6个月且以上的496例患者的24个月内,CVD发生的比率,以及CVD发生与未发生患者中血清降钙素原( PCT)、D-二聚体( D-Dimer)、白细胞介素-6 (IL-6)、白细胞计数及中性粒细胞、超敏C反应蛋白(CRP)的表达水平的差异. 结果 1496例患者中在24个月内发生CVD的患者为29例(29/496,5. 85%),其中高血压发病率最高(3. 23,16/496). HCV感染患者发生CVD的患者中炎症指标与未发生CVD的患者之间存在差异,随着感染时间延长CVD发病率增加,在相关性统计分析中,PCT、D-Dimer、IL-6、NE%的表达量与CVD发生率呈正相关,其中D-Dimer与HCV持续感染发生CVD的相关性最高. 结论 HCV感染患者中炎症指标PCT、D-Dimer、IL-6、NE%高水平与CVD发生有密切相关性,HCV持续感染患者中除开展常规的检查外,可能需要积极防治或排查CVD发生.
目的 分析持續感染HCV患者中心血管疾病( cardivascular disease, CVD)的髮病與血清學炎癥因子錶達水平的相關性,探討HCV感染患者中CVD髮病可能的相關因素. 方法 分析HCV-DNA( +)6箇月且以上的496例患者的24箇月內,CVD髮生的比率,以及CVD髮生與未髮生患者中血清降鈣素原( PCT)、D-二聚體( D-Dimer)、白細胞介素-6 (IL-6)、白細胞計數及中性粒細胞、超敏C反應蛋白(CRP)的錶達水平的差異. 結果 1496例患者中在24箇月內髮生CVD的患者為29例(29/496,5. 85%),其中高血壓髮病率最高(3. 23,16/496). HCV感染患者髮生CVD的患者中炎癥指標與未髮生CVD的患者之間存在差異,隨著感染時間延長CVD髮病率增加,在相關性統計分析中,PCT、D-Dimer、IL-6、NE%的錶達量與CVD髮生率呈正相關,其中D-Dimer與HCV持續感染髮生CVD的相關性最高. 結論 HCV感染患者中炎癥指標PCT、D-Dimer、IL-6、NE%高水平與CVD髮生有密切相關性,HCV持續感染患者中除開展常規的檢查外,可能需要積極防治或排查CVD髮生.
목적 분석지속감염HCV환자중심혈관질병( cardivascular disease, CVD)적발병여혈청학염증인자표체수평적상관성,탐토HCV감염환자중CVD발병가능적상관인소. 방법 분석HCV-DNA( +)6개월차이상적496례환자적24개월내,CVD발생적비솔,이급CVD발생여미발생환자중혈청강개소원( PCT)、D-이취체( D-Dimer)、백세포개소-6 (IL-6)、백세포계수급중성립세포、초민C반응단백(CRP)적표체수평적차이. 결과 1496례환자중재24개월내발생CVD적환자위29례(29/496,5. 85%),기중고혈압발병솔최고(3. 23,16/496). HCV감염환자발생CVD적환자중염증지표여미발생CVD적환자지간존재차이,수착감염시간연장CVD발병솔증가,재상관성통계분석중,PCT、D-Dimer、IL-6、NE%적표체량여CVD발생솔정정상관,기중D-Dimer여HCV지속감염발생CVD적상관성최고. 결론 HCV감염환자중염증지표PCT、D-Dimer、IL-6、NE%고수평여CVD발생유밀절상관성,HCV지속감염환자중제개전상규적검사외,가능수요적겁방치혹배사CVD발생.
Objective To analyze the relationship between onset of CVD and the circulating level of inflammatory factors levels and identified the related elements in occurrence of CVD in HCV infected patients. Methods Analyzed 496 patients of HCV-DNA ( +) above 6 months the ratio of CVD within 24 months, the ratio of CVD, and compared the level of procalcitonin (PCT), two D-dimer(D-Dimer), interleukin-6(IL-6), white blood cells and neutrophils, high sensitive C reactive protein (CRP) expression between CVD+ and CVD-. Results 496 patients with CVD occurred 29 cases (29/496,5. 85%) within 24 months, the incidenceofhypertension was highest(3. 23,16/496). There are differences of inflammatory markers between patients with CVD and without CVD after persistently infected by HCV,the prolonging infection was accompany with increasing incidence of CVD. Ac-cording to relationship statistical analysis, the positive correlation between incidence of CVD and PCT, D-Dimer, IL-6, NE% was discovered, the highest correlation was found between D-Dimer and incidence of CVD. Conclusion The close correlation between high level of inflammatory markers, including PCT, D-Dimer, IL-6, NE%, and CVD was found. The results showed that the sus-taining infection of HCV should be cared the occurrence of CVD, excepting normal checking.
