四川医学
四川醫學
사천의학
Sichuan Medical Journal
2015年
9期
1249-1252
,共4页
心脏骤停%心肺复苏%脑尿钠肽
心髒驟停%心肺複囌%腦尿鈉肽
심장취정%심폐복소%뇌뇨납태
cardiac arrest%cardiopulmonary resuscitation%B-type natriuretic peptide
目的：探讨外周静脉血脑尿钠肽( B-type natriureitic peptide,BNP)与心肺复苏( Cardiopulmonary Resuscita-tion,CPR)预后的关系。方法98例心脏骤停的CPR患者,根据复苏效果分为A组(42例)：CPR 0．5h无效死亡。 B组(21例)：CPR成功,自主循环恢复(recovery of spontaneous circulation,ROSC)≥24h,但在24h后本次住院内死亡。 C组(35例)：CPR成功,本次康复出院。 D组(20例)：对照组,为20例健康体检者。 CPR即刻0h、0．5h、4h、8h、12h及24h分别抽取外周静脉血2mL,对照组早晨空腹抽取外周血2mL,测定全血BNP含量。比较各组患者该指标的动态变化。结果CPR即刻0h：A、B和C三组患者BNP均值水平高,与D组比较,差异有统计学意义(P<0．05)。 B组0h~24hBNP表达持续上升,C组在0h~8hBNP表达持续上升到顶点,8h~24hBNP表达逐渐下降。结论 CPR过程中,BNP的表达呈动态变化,BNP的大量表达提示预后不良。
目的：探討外週靜脈血腦尿鈉肽( B-type natriureitic peptide,BNP)與心肺複囌( Cardiopulmonary Resuscita-tion,CPR)預後的關繫。方法98例心髒驟停的CPR患者,根據複囌效果分為A組(42例)：CPR 0．5h無效死亡。 B組(21例)：CPR成功,自主循環恢複(recovery of spontaneous circulation,ROSC)≥24h,但在24h後本次住院內死亡。 C組(35例)：CPR成功,本次康複齣院。 D組(20例)：對照組,為20例健康體檢者。 CPR即刻0h、0．5h、4h、8h、12h及24h分彆抽取外週靜脈血2mL,對照組早晨空腹抽取外週血2mL,測定全血BNP含量。比較各組患者該指標的動態變化。結果CPR即刻0h：A、B和C三組患者BNP均值水平高,與D組比較,差異有統計學意義(P<0．05)。 B組0h~24hBNP錶達持續上升,C組在0h~8hBNP錶達持續上升到頂點,8h~24hBNP錶達逐漸下降。結論 CPR過程中,BNP的錶達呈動態變化,BNP的大量錶達提示預後不良。
목적：탐토외주정맥혈뇌뇨납태( B-type natriureitic peptide,BNP)여심폐복소( Cardiopulmonary Resuscita-tion,CPR)예후적관계。방법98례심장취정적CPR환자,근거복소효과분위A조(42례)：CPR 0．5h무효사망。 B조(21례)：CPR성공,자주순배회복(recovery of spontaneous circulation,ROSC)≥24h,단재24h후본차주원내사망。 C조(35례)：CPR성공,본차강복출원。 D조(20례)：대조조,위20례건강체검자。 CPR즉각0h、0．5h、4h、8h、12h급24h분별추취외주정맥혈2mL,대조조조신공복추취외주혈2mL,측정전혈BNP함량。비교각조환자해지표적동태변화。결과CPR즉각0h：A、B화C삼조환자BNP균치수평고,여D조비교,차이유통계학의의(P<0．05)。 B조0h~24hBNP표체지속상승,C조재0h~8hBNP표체지속상승도정점,8h~24hBNP표체축점하강。결론 CPR과정중,BNP적표체정동태변화,BNP적대량표체제시예후불량。
Objective To explore the prognostic value of BNP in patients with CPR. Methods A total of 98 patients with sudden cardiac arrest were divided into 3 groups according to the effect of Cardiopulmonary Resuscitation. 42 patients were all died in group A after CPR for half an hour. 21 patients in group B were all died during this hospitalization after the return of spon-taneous circulation for 24 hours. 35 patients in group C were all survival to hospital discharge. Group D, ased the control group, were composed of 20 healthy peoples. In group A, B, and/C, peripheral venous blood(2ml)were taken to measure the BNP con-centration at the time of 0h、0. 5h、4h、8h、12h and 24h after CPR Blood samples(2ml) of the control group were taken at early morning on an empty stomachall. Results Compared with control group D, the BNP level in Group A, B and C were all statisti-cally significant higher(P<0. 05)at the time of 0h. The BNP level in Group B expressed continuing ascending during 24h. The BNP level in Group C expressed continuing ascending and reached the peak at 8h, then declined gradually during 8~24h. Con-clusion During CPR, the expression of BNP showed dynamic changes. Higher BNP level indicateed poor prognosis.
