CAJ | 학술논문

诱导多能干细胞是由动物体细胞重编程得到的，具有胚胎干细胞特性的全能干细胞。近年来，随着多能干细胞诱导技术的不断优化，以及体外分化技术的飞速发展，多种分化状态的多能干细胞被用于移植实验。我们结合最新研究进展，阐述各种分化阶段iPS 细胞用于动物移植治疗的优缺点，以及最新移植方法所存在的问题。
유도다능간세포시유동물체세포중편정득도적，구유배태간세포특성적전능간세포。근년래，수착다능간세포유도기술적불단우화，이급체외분화기술적비속발전，다충분화상태적다능간세포피용우이식실험。아문결합최신연구진전，천술각충분화계단iPS 세포용우동물이식치료적우결점，이급최신이식방법소존재적문제。
[Summary] Induced pluripotent stem cells (iPSCs) derived from reprogrammed somatic cells, are totipotential cells similar to embryonic stem cells. Recently, iPSCs inducing technology has been promptly improved in methods of induction and differentiation in vitro. Consequently, iPSCs at different differentiated stages have been widely used in cell transplantation experiments. Here, the current researches of iPSCs transplantation were summarized, some novel methods comparing with the older one and some problems need to be resolved before iPSCs could be applied in clinic therapy were all reviewed.