CAJ | 학술논문

目的：探讨骨肉瘤患者血清中血管生成素－2（Ang －2）与血管内皮生长因子（VEGF）的含量和临床意义。方法：收集40例骨肉瘤患者和健康志愿者的血清，采用 ELISA 方法检测血清中 Ang －2和 VEGF 的含量，并分析其与临床病理资料和预后的相关性。结果：骨肉瘤患者血清中 VEGF（1234．6±824．5）pg／ml 和Ang －2（1035．5±590．2）pg／ml 的含量明显高于正常对照组血清中 VEGF（334．6±104．2）pg／ml 和 Ang －2（460．3±120．6）pg／ml 的含量（P ＜0．01）。血清 VEGF 和 Ang －2的含量与骨肉瘤的大小、分期及肺内转移明显相关（P ＜0．01）。血清中 Ang －2和 VEGF 高表达的患者的总生存时间明显低于低表达患者（P ＜0．01）。结论：Ang －2和 VEGF 与骨肉瘤的发展和预后密切相关，可能成为骨肉瘤预后判断的标志物。
목적：탐토골육류환자혈청중혈관생성소－2（Ang －2）여혈관내피생장인자（VEGF）적함량화림상의의。방법：수집40례골육류환자화건강지원자적혈청，채용 ELISA 방법검측혈청중 Ang －2화 VEGF 적함량，병분석기여림상병리자료화예후적상관성。결과：골육류환자혈청중 VEGF（1234．6±824．5）pg／ml 화Ang －2（1035．5±590．2）pg／ml 적함량명현고우정상대조조혈청중 VEGF（334．6±104．2）pg／ml 화 Ang －2（460．3±120．6）pg／ml 적함량（P ＜0．01）。혈청 VEGF 화 Ang －2적함량여골육류적대소、분기급폐내전이명현상관（P ＜0．01）。혈청중 Ang －2화 VEGF 고표체적환자적총생존시간명현저우저표체환자（P ＜0．01）。결론：Ang －2화 VEGF 여골육류적발전화예후밀절상관，가능성위골육류예후판단적표지물。
Objective:To investigate the expression and significance of vascular endothelial growth factor(VEGF) and angiopoietins -2(Ang -2)in osteosarcoma patients.Methods:The serum levels of VEGF and Ang -2 in 40 ca-ses of patients with osteosarcoma were detected by ELISA.Their relations with the pathological features and prognosis were analyzed.Results:The serum levels of VEGF and Ang -2 were up -regulated in osteosarcoma patients as com-pared with control group (P <0.01).The serum levels of VEGF and Ang -2 in osteosarcoma patients were associated with tumor size,lung metastasis and stages (P <0.01).Over survival in low serum levels of VEGF or Ang -2 were longer than those in high serum levels (P <0.01).Conclusion:The serum levels of VEGF or Ang -2,correlated with the development and metastasis of the osteosarcoma,may be a valuable parameter for prognostic of osteosarcoma.