现代肿瘤医学
現代腫瘤醫學
현대종류의학
Journal of Modern Oncology
2015年
20期
3012-3015
,共4页
刘少颜%杨瞸鑫%林琼燕%陈辉%陈娟%江庆萍%熊汉真
劉少顏%楊瞸鑫%林瓊燕%陳輝%陳娟%江慶萍%熊漢真
류소안%양엽흠%림경연%진휘%진연%강경평%웅한진
I 型子宫内膜样腺癌%syndecan -2%E -钙黏蛋白%肿瘤转移%预后
I 型子宮內膜樣腺癌%syndecan -2%E -鈣黏蛋白%腫瘤轉移%預後
I 형자궁내막양선암%syndecan -2%E -개점단백%종류전이%예후
type I endometrial carcinoma%syndecan -2%E -Ca%tumor metastasis%prognosis
目的:检测 I 型子宫内膜样腺癌组织中 syndecan -2和 E -钙黏蛋白的表达情况,探讨二者在 I 型子宫内膜样腺癌发生发展及侵袭转移中的作用。方法:应用免疫组织化学 SP 法同步检测65例 I 型子宫内膜样腺癌中的 syndecan -2和 E -钙黏蛋白的表达,取同期65例正常子宫内膜组织做对照。数据采用 SPSS 13.0软件处理,等级资料进行秩和检验。结果:Syndecan -2及 E -钙黏蛋白在 I 型子宫内膜样腺癌中阳性表达率分别为43%及66%,均低于正常子宫内膜组(100%)。同时,syndecan -2阳性表达与 I 型子宫内膜样腺癌的组织学分级无明显相关,但与 FIGO 分期、淋巴结转移、肌层浸润深度呈正相关。相反,E -钙黏蛋白阳性表达与 I 型子宫内膜样腺癌的组织学分级、FIGO 分期、淋巴结转移、肌层浸润深度呈负相关。结论:与正常子宫内膜相比,syndecan -2和 E -钙黏蛋白在 I 型子宫内膜样腺癌中表达减少,syndecan -2高表达、E -钙黏蛋白低表达提示 I 型子宫内膜样腺癌分期晚、预后不良。
目的:檢測 I 型子宮內膜樣腺癌組織中 syndecan -2和 E -鈣黏蛋白的錶達情況,探討二者在 I 型子宮內膜樣腺癌髮生髮展及侵襲轉移中的作用。方法:應用免疫組織化學 SP 法同步檢測65例 I 型子宮內膜樣腺癌中的 syndecan -2和 E -鈣黏蛋白的錶達,取同期65例正常子宮內膜組織做對照。數據採用 SPSS 13.0軟件處理,等級資料進行秩和檢驗。結果:Syndecan -2及 E -鈣黏蛋白在 I 型子宮內膜樣腺癌中暘性錶達率分彆為43%及66%,均低于正常子宮內膜組(100%)。同時,syndecan -2暘性錶達與 I 型子宮內膜樣腺癌的組織學分級無明顯相關,但與 FIGO 分期、淋巴結轉移、肌層浸潤深度呈正相關。相反,E -鈣黏蛋白暘性錶達與 I 型子宮內膜樣腺癌的組織學分級、FIGO 分期、淋巴結轉移、肌層浸潤深度呈負相關。結論:與正常子宮內膜相比,syndecan -2和 E -鈣黏蛋白在 I 型子宮內膜樣腺癌中錶達減少,syndecan -2高錶達、E -鈣黏蛋白低錶達提示 I 型子宮內膜樣腺癌分期晚、預後不良。
목적:검측 I 형자궁내막양선암조직중 syndecan -2화 E -개점단백적표체정황,탐토이자재 I 형자궁내막양선암발생발전급침습전이중적작용。방법:응용면역조직화학 SP 법동보검측65례 I 형자궁내막양선암중적 syndecan -2화 E -개점단백적표체,취동기65례정상자궁내막조직주대조。수거채용 SPSS 13.0연건처리,등급자료진행질화검험。결과:Syndecan -2급 E -개점단백재 I 형자궁내막양선암중양성표체솔분별위43%급66%,균저우정상자궁내막조(100%)。동시,syndecan -2양성표체여 I 형자궁내막양선암적조직학분급무명현상관,단여 FIGO 분기、림파결전이、기층침윤심도정정상관。상반,E -개점단백양성표체여 I 형자궁내막양선암적조직학분급、FIGO 분기、림파결전이、기층침윤심도정부상관。결론:여정상자궁내막상비,syndecan -2화 E -개점단백재 I 형자궁내막양선암중표체감소,syndecan -2고표체、E -개점단백저표체제시 I 형자궁내막양선암분기만、예후불량。
Objective:To investigate the expression of syndecan -2 and E -cadherin(E -Ca)in type I endome-trial carcinoma,find the evidence for early diagnosis and treatment of endometrial carcinoma.Methods:A total of 65 specimens of endometrial carcinoma and 65 normal endometrium were studied by immunohistochemical methed to test the expression of syndecan -2 and E -Ca.SPSS 13.0 software was used for data processing,rank sum test for ranked data.Results:Positive expression rate of syndecan -2 and E -Ca in type I endometrial carcinoma was respectively 43% and 66% ,which was all lower than that in normal endometrium 100%.Positive expression of syndecan -2 was positively correlated with FIGO stage,lymphatic metastasis and muscular infiltration of endometrial carcinoma without tumor trade.Positive expression of E -Ca was negatively correlated with tumor grade,FIGO stage,lymphatic metasta-sis and muscular infiltration of endometrial carcinoma.Conclusion:Compared to normal endometrium,syndecan -2 and E -cadherin expression was decreased in endometrial carcinoma.The high expression of syndecan -2 with low expression of E -Ca is significantly correlated with endometrial carcinogenesis,and it may further promote metastasis and poor outcome of endometrial carcinoma.