CAJ | 학술논문

目的：探讨钙结合蛋白 S100A6（calcyclin，Cacy）在卵巢上皮性癌中的表达及临床意义。方法：采用免疫组化技术检测60例卵巢癌病理组织标本中 S100A6的蛋白表达情况，分析 S100A6与卵巢癌的发生发展的关系，探讨 S100A6与卵巢上皮性癌临床病理因素之间的相关性。结果：S100A6表达水平与病理类型无关（P ＞0．05），与细胞分化程度有关，低分化的卵巢癌患者中 S100A6高表达比例为66．7％，而在高分化的卵巢癌患者中 S100A6高表达比例为15．4％，有统计学差异（P ＜0．05）。S100A6表达水平与手术分期有关，随着手术分期的增加，S100A6表达水平也随之明显上升，有统计学差异（P ＜0．05）。同时我们还发现，S100A6表达水平和腹水、淋巴结转移有关。在出现腹水和淋巴结转移的卵巢癌患者中，S100A6高表达的比例明显增加，有统计学意义（P ＜0．001）。结论：S100A6表达和与卵巢癌的发生发展、侵袭转移和不良预后密切相关，有可能成为临床评价病情进展和随访的参考指标。
목적：탐토개결합단백 S100A6（calcyclin，Cacy）재란소상피성암중적표체급림상의의。방법：채용면역조화기술검측60례란소암병리조직표본중 S100A6적단백표체정황，분석 S100A6여란소암적발생발전적관계，탐토 S100A6여란소상피성암림상병리인소지간적상관성。결과：S100A6표체수평여병리류형무관（P ＞0．05），여세포분화정도유관，저분화적란소암환자중 S100A6고표체비례위66．7％，이재고분화적란소암환자중 S100A6고표체비례위15．4％，유통계학차이（P ＜0．05）。S100A6표체수평여수술분기유관，수착수술분기적증가，S100A6표체수평야수지명현상승，유통계학차이（P ＜0．05）。동시아문환발현，S100A6표체수평화복수、림파결전이유관。재출현복수화림파결전이적란소암환자중，S100A6고표체적비례명현증가，유통계학의의（P ＜0．001）。결론：S100A6표체화여란소암적발생발전、침습전이화불량예후밀절상관，유가능성위림상평개병정진전화수방적삼고지표。
Objective:To explore the expression of S100A6 in ovarian cancer and its clinical significance.Meth-ods:In order to find out the clinical significance of S100A6 in ovarian cancer,the expression of S100A6 were tested by immunohistochemistry in the ovarian cancer tissues.Results:Immunohistochemical analysis showed that the S100A6 protein cytoplasm expression was common in ovarian cancer tissues.The percentage of high level of S100A6 expression was 66.7% in poorly differentiated ovarian cancer tissues,and the percentage of high level of S100A6 ex-pression was only 15.4% in well differentiated ovarian cancer tissues.High expression of S100A6 protein was associ-ated with surgical stages,malignant ascites and lymphatic metastasis in ovarian cancer.Conclusion:The expression of S100A6 protein was closely associated with progress,invasion and metastasis,and poor prognosis in ovarian cancer. S100A6 may be involved in the ovarian cancer pathogenesis.