国际老年医学杂志
國際老年醫學雜誌
국제노년의학잡지
international Journal of Geriatrics
2015年
5期
206-209
,共4页
胃泌素%幽门螺杆菌%Survivin抗体%胃炎%胃癌
胃泌素%幽門螺桿菌%Survivin抗體%胃炎%胃癌
위비소%유문라간균%Survivin항체%위염%위암
Gastrin%Helicobacter pylori%Survivin antibodies%Gastritis%Gastric
目的：：研究胃泌素、幽门螺杆菌( Hp)及T细胞联合检测在老年胃炎病情发展及预后的评估中的意义,从而为老年胃炎病情发展的病情评估、疗效评价及预后判断提供帮助。方法：选择2010~2013年在我院消化内镜室胃镜检查的老年人共585人,134例患者均经胃镜检查确诊为慢性胃炎,78例患者被确诊为胃癌。这些患者在治疗前,清晨取空腹患者肘静脉血5ml,用酶联免疫吸附法进行胃泌素及血清survivin抗体检测,同时进行快速尿素酶试验检测幽门螺杆菌检测,对结果进行统计学分析。结果： Hp 检测阳性率为49.8%,伴随诊断出的十二指肠炎阳性率为13.5%、消化性溃疡为13.1%、反流性食道炎为11.3%、胃息肉为6.1%。胃癌组早期和中后期血清中survivin抗体的浓度值明显高于正常对照组,差异显著( t值分别为2.595和6.451,P <0.05)；胃癌组早期和中后期血清中胃泌素的浓度值明显高于正常对照组,差异显著( t值分别为2.981和5.891,P <0.05)。胃泌素及血清survivin抗体含量与病理组织中检测的结果保持一致。结论： Hp检测提高胃炎检出率,血清Survivin抗体和胃泌素含量在胃癌时明显增高,与胃癌的发生、发展和组织分化程度关系密切；联合检测有助于胃癌筛查、病情监测、疗效评价和预后判断。
目的：：研究胃泌素、幽門螺桿菌( Hp)及T細胞聯閤檢測在老年胃炎病情髮展及預後的評估中的意義,從而為老年胃炎病情髮展的病情評估、療效評價及預後判斷提供幫助。方法：選擇2010~2013年在我院消化內鏡室胃鏡檢查的老年人共585人,134例患者均經胃鏡檢查確診為慢性胃炎,78例患者被確診為胃癌。這些患者在治療前,清晨取空腹患者肘靜脈血5ml,用酶聯免疫吸附法進行胃泌素及血清survivin抗體檢測,同時進行快速尿素酶試驗檢測幽門螺桿菌檢測,對結果進行統計學分析。結果： Hp 檢測暘性率為49.8%,伴隨診斷齣的十二指腸炎暘性率為13.5%、消化性潰瘍為13.1%、反流性食道炎為11.3%、胃息肉為6.1%。胃癌組早期和中後期血清中survivin抗體的濃度值明顯高于正常對照組,差異顯著( t值分彆為2.595和6.451,P <0.05)；胃癌組早期和中後期血清中胃泌素的濃度值明顯高于正常對照組,差異顯著( t值分彆為2.981和5.891,P <0.05)。胃泌素及血清survivin抗體含量與病理組織中檢測的結果保持一緻。結論： Hp檢測提高胃炎檢齣率,血清Survivin抗體和胃泌素含量在胃癌時明顯增高,與胃癌的髮生、髮展和組織分化程度關繫密切；聯閤檢測有助于胃癌篩查、病情鑑測、療效評價和預後判斷。
목적：：연구위비소、유문라간균( Hp)급T세포연합검측재노년위염병정발전급예후적평고중적의의,종이위노년위염병정발전적병정평고、료효평개급예후판단제공방조。방법：선택2010~2013년재아원소화내경실위경검사적노년인공585인,134례환자균경위경검사학진위만성위염,78례환자피학진위위암。저사환자재치료전,청신취공복환자주정맥혈5ml,용매련면역흡부법진행위비소급혈청survivin항체검측,동시진행쾌속뇨소매시험검측유문라간균검측,대결과진행통계학분석。결과： Hp 검측양성솔위49.8%,반수진단출적십이지장염양성솔위13.5%、소화성궤양위13.1%、반류성식도염위11.3%、위식육위6.1%。위암조조기화중후기혈청중survivin항체적농도치명현고우정상대조조,차이현저( t치분별위2.595화6.451,P <0.05)；위암조조기화중후기혈청중위비소적농도치명현고우정상대조조,차이현저( t치분별위2.981화5.891,P <0.05)。위비소급혈청survivin항체함량여병리조직중검측적결과보지일치。결론： Hp검측제고위염검출솔,혈청Survivin항체화위비소함량재위암시명현증고,여위암적발생、발전화조직분화정도관계밀절；연합검측유조우위암사사、병정감측、료효평개화예후판단。
OBJECTIVE: To study changes of the content of gastrin Hp and survivin antibody in the serum of the elderly gastritis which can be helpful for screening, condition assessment, evaluation of curative effect and prognosis judgment of the gastric cancer. METHODS: Total 585 elderly people were diagnosed by endoscopy in 2010 to 2013 in our hospital. Among them 134 patients were chronic gastritis and 78 patients were stomach cancer. The contents of survivin antibody and GAS were detected by ELISA method. Simultaneous Helicobacter pylori was also detected. Then the results were anlysised by statistics. RESULTS: The concentrations of survivin antibody in the serum of early gastric carcinoma group and later gastric carcinoma group were obviously higher than that in the normal group ( t =2. 595 and 6. 451, P <0. 05); the concentrations of gastrin in serum of early gastric carcinoma group and later gastric carcinoma group were also obviously higher than that in the normal group ( t =2. 981 and 5. 891, P <0. 05), which was con-sistent with the results of the detection of pathological tissues. CONCLUSION: Hp can improve the detection of gastritis. The content of survivin antibody and GAS is significantly increased in gastric cancer. It is positively correlated between the survivin antibody and GAS and it is closely related to occurrence and development and differentiation degree of gastric cancer, which may be helpful for screening gastric cancer, monitoring condition, evaluating curative effect and judging prognosis.
