CAJ | 학술논문

通过中国知网、重庆维普、万方数据库中收集2009年-2015年治疗股骨头坏死的中药处方，基于中医传承辅助平台 V2.5（TCMISS V2.5）软件分析股骨头坏死中药处方的用药规律。采用关联规则 apriori 算法、复杂系统熵聚类等无监督数据挖掘方法，分析处方中各种药物的使用频次、药物之间的关联规则、核心药物组合。对筛选出的161个中药处方进行分析，确定处方中药物的使用频次，药物之间的关联规则，挖掘出24个核心组合。股骨头坏死常用的药物以活血化瘀药、补血药、补气药、补阳药等为主，治法主要是补益肝肾、活血化瘀。牛膝、当归、丹参、骨碎补、甘草、黄芪、续断、熟地黄、淫羊藿、红花、桃仁、三七、茯苓、土鳖虫、赤芍、白芍是临床治疗股骨头坏死常用的核心药物。
통과중국지망、중경유보、만방수거고중수집2009년-2015년치료고골두배사적중약처방，기우중의전승보조평태 V2.5（TCMISS V2.5）연건분석고골두배사중약처방적용약규률。채용관련규칙 apriori 산법、복잡계통적취류등무감독수거알굴방법，분석처방중각충약물적사용빈차、약물지간적관련규칙、핵심약물조합。대사선출적161개중약처방진행분석，학정처방중약물적사용빈차，약물지간적관련규칙，알굴출24개핵심조합。고골두배사상용적약물이활혈화어약、보혈약、보기약、보양약등위주，치법주요시보익간신、활혈화어。우슬、당귀、단삼、골쇄보、감초、황기、속단、숙지황、음양곽、홍화、도인、삼칠、복령、토별충、적작、백작시림상치료고골두배사상용적핵심약물。
The Chinese herbal formulas for the treatment of femoral head necrosis were retrieved from CNKI,Chongqing VIP and Wanfang database from 2009 to 2015. Based on TCMISS V2. 5 software,the medication law of herbal medicines was analyzed for the treatment of femoral head necrosis. The use frequen-cy of each medicine in the formulas,the association rules among medicines and the combination of core medi-cines were analyzed with non - supervision data mining methods such as apriori algorithm and the complex system entropy cluster. One hundred and sixteen herbal medicine formulas were screened for analysis and de-termined the use frequency,the association rules and had explored 24 core combinations. The herbs in the categories of activating blood circulation and removing stasis,tonifying blood and tonifying qi were commonly used. The main principles were tonifying the liver and kidney,activating blood circulation,resolving stasis, tonifying blood,qi and yang. The core medicines in clinical treatment of necrosis were radix achyranthis bi-dentatae,angelica sinenesis,salvia miltiorrhiza,rhizome drynariae,glycyrrhiza,radix astragali,radix dipsaci, radix rehmanniae praeparata,herba epimedii,safflower carthamus,semen persicae,panax pseudoginseng,poria cocs,eupolyphaga,radix paeoniae rubra and radix paeoniae alba.