CAJ | 학술논문

目的：：探讨急性脑梗死患者OCSP分型与凝血酶原片段1+2和抗凝血酶3的相关性。方法：对入住我院神经内二科的64例患急性脑梗死患者进行OCSP分型，并选择门诊健康体检者作对照。应用酶联免疫吸附法( ELISA)进行检测所有患者的血浆凝血酶原片段1+2浓度和抗凝血酶3活性；分析两者与急性脑梗死OCSP分型的相关性。结果：急性脑梗死各亚型中，完全前循环性脑梗死( TACI)、部分前循环性脑梗死( PACI)和后循环性脑梗死( POCI)患者血浆凝血酶原片段1+2浓度明显高于腔隙性脑梗死( LACI)和健康对照者，抗凝血酶3活性明显低于腔隙性脑梗死和健康对照者。结论：血浆凝血酶原片段1+2浓度和抗凝血酶3活性的增高与TACI及PACI密切相关。
목적：：탐토급성뇌경사환자OCSP분형여응혈매원편단1+2화항응혈매3적상관성。방법：대입주아원신경내이과적64례환급성뇌경사환자진행OCSP분형，병선택문진건강체검자작대조。응용매련면역흡부법( ELISA)진행검측소유환자적혈장응혈매원편단1+2농도화항응혈매3활성；분석량자여급성뇌경사OCSP분형적상관성。결과：급성뇌경사각아형중，완전전순배성뇌경사( TACI)、부분전순배성뇌경사( PACI)화후순배성뇌경사( POCI)환자혈장응혈매원편단1+2농도명현고우강극성뇌경사( LACI)화건강대조자，항응혈매3활성명현저우강극성뇌경사화건강대조자。결론：혈장응혈매원편단1+2농도화항응혈매3활성적증고여TACI급PACI밀절상관。
OBJECTIVE: To explore the relationship between OCSP classification of acute cerebral infarction and prothrombin fragment 1+2 and antithrombin 3. METHODS: 64 hospitalized patients with acute cerebral infarction were enrolled by OCSP classifi-cation. The health outpatients were control group. By the method of enzyme-linked immunosorbent ( ELISA) plasma prothrombin fragment 1+2 concentration and antithrombin activity were tested. The relationship between OCSP classification of acute cerebral in-farction and both of two indexes was analysed. RESULTS: In cerebral infarction of completely before cycle ( TACI) , part of the cy-clical cerebral infarction ( PACI) before and after the circularity of patients with brain infarction ( POCI) plasma prothrombin fragment 1+2 concentration was significantly higher than that of lacunar cerebral infarction ( LACI) and healthy control group. Antithrombin activity 3 was significantly lower than that of the lacunar cerebral infarction and healthy control group. CONCLUSION:Increasing plas-ma prothrombin fragment 1+2 concentration and the three antithrombin activity are closely related to the TACI and PACI.