CAJ | 학술논문

目的：探讨血清 CA72－4、CEA 及 CA19－9水平与胃癌患者病理特征的相关性。方法：选择2011年6月－2013年3月收治的86例胃癌患者，56例胃良性肿瘤患者，60例普通胃病患者，比较三组患者 CA72－4、CA19－9和 CEA 水平；CA72－4、CA19－9和 CEA 单项检测及联合检测胃癌患者的阳性率；CA72－4、CA19－9和 CEA 水平与胃癌病理特征的关系。结果：胃癌组患者血清 CA72－4、CA19－9和 CEA 水平均高于胃良性肿瘤组患者（P ＜0．05），胃癌良性组患者均高于对照组（P ＜0．05）；三种胃癌肿瘤标志物中 CA72－4诊断胃癌的阳性率最高，肿瘤3项标志物的阳性检测率要显著高于单项 CA72－4、CA19－9、CEA 的阳性检出率（P＜0．05）；肿瘤越大、TNM分期越高，CA72－4、CA19－9和 CEA 水平越高。结论：采用 CA72－4、CA19－9和CEA 联合检测是诊断胃癌比较理想的组合。CA72－4、CA19－9和 CEA 水平的变化可以反应胃癌患者的病理特征。
목적：탐토혈청 CA72－4、CEA 급 CA19－9수평여위암환자병리특정적상관성。방법：선택2011년6월－2013년3월수치적86례위암환자，56례위량성종류환자，60례보통위병환자，비교삼조환자 CA72－4、CA19－9화 CEA 수평；CA72－4、CA19－9화 CEA 단항검측급연합검측위암환자적양성솔；CA72－4、CA19－9화 CEA 수평여위암병리특정적관계。결과：위암조환자혈청 CA72－4、CA19－9화 CEA 수평균고우위량성종류조환자（P ＜0．05），위암량성조환자균고우대조조（P ＜0．05）；삼충위암종류표지물중 CA72－4진단위암적양성솔최고，종류3항표지물적양성검측솔요현저고우단항 CA72－4、CA19－9、CEA 적양성검출솔（P＜0．05）；종류월대、TNM분기월고，CA72－4、CA19－9화 CEA 수평월고。결론：채용 CA72－4、CA19－9화CEA 연합검측시진단위암비교이상적조합。CA72－4、CA19－9화 CEA 수평적변화가이반응위암환자적병리특정。
Objective:To investigate serum CA72 -4,CEA and CA19 -9 levels and pathological features of pa-tients with gastric cancer.Methods:In 86 cases of gastric cancer CA72 -4,CA19 -9 and CEA levels were tested and pathological features with gastric cancer were analyzed.Results:In the serum of patients with gastric cancer CA72 -4,CA19 -9 and CEA levels were significantly higher than the group of patients with benign gastric diseases(P <0.05).The positive rats of combined three gastric tumor markers was significantly higher than single one(P <0.05). The larger of the tumor,the later of TNMstage,the higher of CA72 -4,CA19 -9 and CEA levels.Conclusion:CA72-4,CA19 -9 and CEA combined detection is an ideal marker in diagnosis of gastric cancer.