临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
Journal of Clinical Psychosomatic Diseases
2015年
5期
136-137
,共2页
酒精性脂肪性肝病%复方二氯二异丙胺%胰岛素增敏剂%二甲双胍%临床疗效%安全性
酒精性脂肪性肝病%複方二氯二異丙胺%胰島素增敏劑%二甲雙胍%臨床療效%安全性
주정성지방성간병%복방이록이이병알%이도소증민제%이갑쌍고%림상료효%안전성
AFLD%CDD%insulin sensitizer%metformin%efficacy%safety
目的:探讨复方二氯二异丙胺治疗酒精性脂肪性肝病患者的临床疗效及安全性。方法将97例酒精性脂肪性肝病患者随机分为两组,研究组54例,对照组43例。研究组静脉滴注复方二氯二异丙胺治疗,对照组常规口服胰岛素增敏剂二甲双胍治疗,观察6周。于治疗6周末,根据血清总胆固醇改善状况判定临床疗效,并统计不良反应发生状况。结果治疗6周末,研究组总有效率为98.1%,对照组为81.4%;两组比较差异有极显著性(P<0.01)。研究组不良反应发生率为7.4%,对照组为14.0%;两组比较差异无显著性(P>0.05)。结论复方二氯二异丙胺治疗酒精性脂肪性肝病患者疗效显著,安全性高,值得在临床广泛推广应用。
目的:探討複方二氯二異丙胺治療酒精性脂肪性肝病患者的臨床療效及安全性。方法將97例酒精性脂肪性肝病患者隨機分為兩組,研究組54例,對照組43例。研究組靜脈滴註複方二氯二異丙胺治療,對照組常規口服胰島素增敏劑二甲雙胍治療,觀察6週。于治療6週末,根據血清總膽固醇改善狀況判定臨床療效,併統計不良反應髮生狀況。結果治療6週末,研究組總有效率為98.1%,對照組為81.4%;兩組比較差異有極顯著性(P<0.01)。研究組不良反應髮生率為7.4%,對照組為14.0%;兩組比較差異無顯著性(P>0.05)。結論複方二氯二異丙胺治療酒精性脂肪性肝病患者療效顯著,安全性高,值得在臨床廣汎推廣應用。
목적:탐토복방이록이이병알치료주정성지방성간병환자적림상료효급안전성。방법장97례주정성지방성간병환자수궤분위량조,연구조54례,대조조43례。연구조정맥적주복방이록이이병알치료,대조조상규구복이도소증민제이갑쌍고치료,관찰6주。우치료6주말,근거혈청총담고순개선상황판정림상료효,병통계불량반응발생상황。결과치료6주말,연구조총유효솔위98.1%,대조조위81.4%;량조비교차이유겁현저성(P<0.01)。연구조불량반응발생솔위7.4%,대조조위14.0%;량조비교차이무현저성(P>0.05)。결론복방이록이이병알치료주정성지방성간병환자료효현저,안전성고,치득재림상엄범추엄응용。
Objective To explore the efficacy and safety of compound dichloride diisopropylamine (CDD) in the treatment of alcoholic fatty liver disease (AFLD) .Methods Ninety‐seven AFLD patients were randomly divided into research (n= 54) and control group (n= 43) .Research group was treated with intravenous CDD and control took orally insulin sensitizer metformin for 6 weeks .Effica‐cies were assessed according to the improvement condition of serum total cholesterol at the end of the 6th week and adverse reactions added up .Results At the end of the 6th week total effective rate was respec‐tively 9 8 .1% in research and 81 .4% in control group ,which showed significant difference ( P < 0 .01) . The incidence of adverse reactions was respectively 7 .4% in research and 14 .0% in control group ,which showed no significant difference (P > 0 .05) .Con‐clusion CDD has an evident effect and high safety in the treatment of AFLD and is worthy of clinical generalization and application .