CAJ | 학술논문

目的：探讨全血微量元素含量与妊娠期糖尿病（GDM ）发生发展的关系以及对GDM孕妇规范治疗的重要性，为GDM的预防及治疗提供理论依据。方法按GDM诊断标准随机选取153例GDM 孕妇为病例组，121例健康孕妇为对照组；采用火焰原子吸收光谱法分别测定病例组和对照组孕妇孕中期和孕晚期全血微量元素（铜、锌、钙、镁、铁）水平，对数据统计处理并进行对照研究。结果（1）GDM 组（孕中期）与对照组（孕中期）在年龄、孕周、身高等方面的差异无统计学意义（P＞0．05）；GDM组（孕中期）孕妇孕前体质量、孕前体质指数BMI均显著高于对照组（孕中期），差异有统计学意义（P＜0．05）；GDM组（孕中期）孕妇孕期增重显著低于对照组（孕中期），差异有统计学意义（P＜0．05）。（2）规范治疗前，GDM组（孕中期）微量元素铜含量显著高于对照组（孕中期），差异有统计学意义（P＜0．05）；GDM组（孕中期）微量元素锌、铁含量显著低于对照组（孕中期），差异有统计学意义（P＜0．05）；GDM组（孕中期）微量元素钙、镁含量与对照组（孕中期）比较，差异无统计学意义（ P＞0．05）。（3）规范治疗后， GDM组（孕晚期）微量元素锌含量显著高于GDM 组（孕中期）及对照组（孕晚期），差异有统计学意义（ P＜0．05）；GDM组（孕晚期）微量元素铜含量显著低于GDM组（孕中期），差异有统计学意义（P＜0．05）；GDM 组（孕晚期）微量元素铜、钙、镁、铁含量与对照组（孕晚期）比较，差异无统计学意义（ P＞0．05）。结论 GDM 是围生期较常见合并症，要高度重视GDM孕妇微量元素代谢紊乱，注重早期防治GDM发生及微量元素的均衡摄入，确保母婴健康。
목적：탐토전혈미량원소함량여임신기당뇨병（GDM ）발생발전적관계이급대GDM잉부규범치료적중요성，위GDM적예방급치료제공이론의거。방법안GDM진단표준수궤선취153례GDM 잉부위병례조，121례건강잉부위대조조；채용화염원자흡수광보법분별측정병례조화대조조잉부잉중기화잉만기전혈미량원소（동、자、개、미、철）수평，대수거통계처리병진행대조연구。결과（1）GDM 조（잉중기）여대조조（잉중기）재년령、잉주、신고등방면적차이무통계학의의（P＞0．05）；GDM조（잉중기）잉부잉전체질량、잉전체질지수BMI균현저고우대조조（잉중기），차이유통계학의의（P＜0．05）；GDM조（잉중기）잉부잉기증중현저저우대조조（잉중기），차이유통계학의의（P＜0．05）。（2）규범치료전，GDM조（잉중기）미량원소동함량현저고우대조조（잉중기），차이유통계학의의（P＜0．05）；GDM조（잉중기）미량원소자、철함량현저저우대조조（잉중기），차이유통계학의의（P＜0．05）；GDM조（잉중기）미량원소개、미함량여대조조（잉중기）비교，차이무통계학의의（ P＞0．05）。（3）규범치료후， GDM조（잉만기）미량원소자함량현저고우GDM 조（잉중기）급대조조（잉만기），차이유통계학의의（ P＜0．05）；GDM조（잉만기）미량원소동함량현저저우GDM조（잉중기），차이유통계학의의（P＜0．05）；GDM 조（잉만기）미량원소동、개、미、철함량여대조조（잉만기）비교，차이무통계학의의（ P＞0．05）。결론 GDM 시위생기교상견합병증，요고도중시GDM잉부미량원소대사문란，주중조기방치GDM발생급미량원소적균형섭입，학보모영건강。
Objective To explore the relationship between the content of trace elements in whole blood with the occurrence and development of gestational diabetes mellitus(GDM ) and its importance for the standard treatment on GDM pregnant women to provide the theoretical basis for the prevention and treatment of GDM .Methods Ac‐cording to the diagnostic criteria of GDM ,153 GDM pregnant women and 121 healthy pregnant women were random‐ly chosen and assigned into the patient group and the control group respectively .The levels of whole blood trace ele‐ments (copper ,zinc ,calcium ,magnesium ,iron) at the middle and late pregnant stages in the two groups were detected by flame atomic absorption spectrometry .Then the data were statistically processed and performed the comparative study .Results (1)There were no significant differences in the aspects of age ,gestational age and height (middle stage) between the GDM group and the control group (P>0 .05);the GDM group was higher than the control group in the prepregnant weight and pre‐pregnant BMI(middle stage) ,the differences were significance(P< 0 .05);the GDM group was lower than the control group in the weight gain during pregnancy (middle stage) ,the differences were statistically significant(P<0 .05) .(2)Before the standard treatment ,the GDM group was higher than the con‐trol group in copper level(middle stage) ,the difference was statistically significance(P<0 .05);while the GDM group was lower than the control group in the zinc and iron levels(middle stage) ,the differences were statistically signifi‐cant(P<0 .05);the levels of calcium and magnesium (middle stage) had no statistically significant differences be‐tween the GDM group and the control group(P>0 .05) .(3)After the standard treatment ,the GDM group(middle stage) was higher than the GDM (late stage) group and the control group(late stage) in the zinc level ,the differences were statistically significant(P<0 .05);the GDM group(late stage) was lower than the GDM group(middle stage) in the copper level ,the difference was statistically significant(P<0 .05);the levels of copper ,calcium ,magnesium and i‐ron elements (late stage) had no statistically significant differences between the GDM group and the control group (P>0 .05) .Conclusion GDM is common complication during pregnancy ,the trace elements metabolism disorders in the GDM pregnant women should be pay great attention to ,in particular ,should focus on early prevention and treat‐ment of GDM happening and strengthen the balance intake of trace elements during pregnant stage so as to ensure maternal and fetal health .