临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
Journal of Clinical Psychosomatic Diseases
2015年
5期
120-122
,共3页
难治性精神分裂症%齐拉西酮%氯氮平%阳性与阴性症状量表%副反应量表
難治性精神分裂癥%齊拉西酮%氯氮平%暘性與陰性癥狀量錶%副反應量錶
난치성정신분렬증%제랍서동%록담평%양성여음성증상량표%부반응량표
TRS%ziprasidone%clozapine%PANSS%TESS
目的：探讨齐拉西酮联合小剂量氯氮平治疗难治性精神分裂症的临床疗效。方法本组41例难治性精神分裂症患者，对单用氯氮平者联合齐拉西酮治疗，单用齐拉西酮者联合小剂量氯氮平治疗，观察12周。采用阳性与阴性症状量表、副反应量表评定疗效及不良反应。结果本组患者阳性与阴性症状量表总分及各因子分均较治疗前显著持续下降（P＜0．05或0．01），显效率为68．3％，总有效率为78．0％，除失眠外其他不良反应发生率均较治疗前降低。结论齐拉西酮联合小剂量氯氮平治疗难治性精神分裂症疗效显著，且安全性高。
目的：探討齊拉西酮聯閤小劑量氯氮平治療難治性精神分裂癥的臨床療效。方法本組41例難治性精神分裂癥患者，對單用氯氮平者聯閤齊拉西酮治療，單用齊拉西酮者聯閤小劑量氯氮平治療，觀察12週。採用暘性與陰性癥狀量錶、副反應量錶評定療效及不良反應。結果本組患者暘性與陰性癥狀量錶總分及各因子分均較治療前顯著持續下降（P＜0．05或0．01），顯效率為68．3％，總有效率為78．0％，除失眠外其他不良反應髮生率均較治療前降低。結論齊拉西酮聯閤小劑量氯氮平治療難治性精神分裂癥療效顯著，且安全性高。
목적：탐토제랍서동연합소제량록담평치료난치성정신분렬증적림상료효。방법본조41례난치성정신분렬증환자，대단용록담평자연합제랍서동치료，단용제랍서동자연합소제량록담평치료，관찰12주。채용양성여음성증상량표、부반응량표평정료효급불량반응。결과본조환자양성여음성증상량표총분급각인자분균교치료전현저지속하강（P＜0．05혹0．01），현효솔위68．3％，총유효솔위78．0％，제실면외기타불량반응발생솔균교치료전강저。결론제랍서동연합소제량록담평치료난치성정신분렬증료효현저，차안전성고。
Objective To explore the efficacy of ziprasidone plus small‐dose cloza‐pine in treatment‐resistant schizophrenia (TRS) .Methods Of 41 TRS patients ones on single clozapine were plus ziprasidone and ones on ziprasidone plus small‐dose clozapine for 12 weeks .Efficacies were as‐sessed with the Positive and Negative Syndrome Scale (PANSS) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results The total and each factor scores of the patients lowered nota‐bly and continuously after treatment compared with pretreatment (P< 0 .05 or 0 .01) ,obvious and total ef‐fective rate were respectively 68 .3% and 78 .0% ,and the incidences of adverse reactions except insomnia lowered .Conclusion Ziprasidone plus small‐dose clozapine has an evident effect and high safety in treat‐ment‐resistant schizophrenia .
