实用癌症杂志
實用癌癥雜誌
실용암증잡지
The Practical Journal of Cancer
2015年
8期
1253-1256
,共4页
化疗所致周围神经病变%硫辛酸%葡萄糖酸钙%硫酸镁%静脉注射%不良反应
化療所緻週圍神經病變%硫辛痠%葡萄糖痠鈣%硫痠鎂%靜脈註射%不良反應
화료소치주위신경병변%류신산%포도당산개%류산미%정맥주사%불량반응
Chemotherapy-induced peripheral neuropathy(CIPN)%Lipoic acid%Calcium gluconate%Magnesium sulfate%Intravenous infusion%Adverse reactions
目的 探讨硫辛酸联合葡萄糖酸钙/硫酸镁对恶性肿瘤化疗药物所致周围神经病变( CIPN)的治疗效果.方法 将179例接受化疗并明确诊断为CIPN的恶性肿瘤患者随机分为对照组(90例)和研究组(89例),对照组患者给予葡萄糖酸钙10 ml和25%硫酸镁10 ml注入5%葡萄糖溶液静脉滴注;研究组患者在对照组治疗的基础上加用α-硫辛酸注射液600 mg入0.9%氯化钠注射液静脉滴注. 2组均治疗24天,观察2组患者治疗前后正中神经和腓总神经的传导速度,采用视觉模拟评分( VAS)评价治疗前后疼痛情况,并评估治疗效果和不良反应. 结果 研究组和对照组治疗后正中神经和腓总神经的传导速度均较治疗前有不同程度的提高(P<0.05、P<0.01),但研究组较对照组神经传导速度提高更显著(P<0.05). 研究组治疗后VAS评分较治疗前显著下降(P<0.05),而对照组治疗前后VAS评分无显著差异(P>0.05). 治疗24天后,研究组治疗总有效率为95.51%(85/89),显著高于对照组的83.33%(75/90)(P<0.05).2组不良反应发生率无显著差异(12.36%vs 8.89%,P>0.05),均无严重不良反应发生. 结论 硫辛酸联合葡萄糖酸钙及硫酸镁能够加快恶性肿瘤CIPN患者感觉及运动神经的传导速度,改善患者的临床症状和体征,具有协同作用,且用药安全,值得临床应用.
目的 探討硫辛痠聯閤葡萄糖痠鈣/硫痠鎂對噁性腫瘤化療藥物所緻週圍神經病變( CIPN)的治療效果.方法 將179例接受化療併明確診斷為CIPN的噁性腫瘤患者隨機分為對照組(90例)和研究組(89例),對照組患者給予葡萄糖痠鈣10 ml和25%硫痠鎂10 ml註入5%葡萄糖溶液靜脈滴註;研究組患者在對照組治療的基礎上加用α-硫辛痠註射液600 mg入0.9%氯化鈉註射液靜脈滴註. 2組均治療24天,觀察2組患者治療前後正中神經和腓總神經的傳導速度,採用視覺模擬評分( VAS)評價治療前後疼痛情況,併評估治療效果和不良反應. 結果 研究組和對照組治療後正中神經和腓總神經的傳導速度均較治療前有不同程度的提高(P<0.05、P<0.01),但研究組較對照組神經傳導速度提高更顯著(P<0.05). 研究組治療後VAS評分較治療前顯著下降(P<0.05),而對照組治療前後VAS評分無顯著差異(P>0.05). 治療24天後,研究組治療總有效率為95.51%(85/89),顯著高于對照組的83.33%(75/90)(P<0.05).2組不良反應髮生率無顯著差異(12.36%vs 8.89%,P>0.05),均無嚴重不良反應髮生. 結論 硫辛痠聯閤葡萄糖痠鈣及硫痠鎂能夠加快噁性腫瘤CIPN患者感覺及運動神經的傳導速度,改善患者的臨床癥狀和體徵,具有協同作用,且用藥安全,值得臨床應用.
목적 탐토류신산연합포도당산개/류산미대악성종류화료약물소치주위신경병변( CIPN)적치료효과.방법 장179례접수화료병명학진단위CIPN적악성종류환자수궤분위대조조(90례)화연구조(89례),대조조환자급여포도당산개10 ml화25%류산미10 ml주입5%포도당용액정맥적주;연구조환자재대조조치료적기출상가용α-류신산주사액600 mg입0.9%록화납주사액정맥적주. 2조균치료24천,관찰2조환자치료전후정중신경화비총신경적전도속도,채용시각모의평분( VAS)평개치료전후동통정황,병평고치료효과화불량반응. 결과 연구조화대조조치료후정중신경화비총신경적전도속도균교치료전유불동정도적제고(P<0.05、P<0.01),단연구조교대조조신경전도속도제고경현저(P<0.05). 연구조치료후VAS평분교치료전현저하강(P<0.05),이대조조치료전후VAS평분무현저차이(P>0.05). 치료24천후,연구조치료총유효솔위95.51%(85/89),현저고우대조조적83.33%(75/90)(P<0.05).2조불량반응발생솔무현저차이(12.36%vs 8.89%,P>0.05),균무엄중불량반응발생. 결론 류신산연합포도당산개급류산미능구가쾌악성종류CIPN환자감각급운동신경적전도속도,개선환자적림상증상화체정,구유협동작용,차용약안전,치득림상응용.
Objective To explore the therapeutic effect of lipoic acid combined with calcium gluconate and magnesium sulfate for malignant tumor chemotherapy-induced peripheral neuropathy ( CIPN) .Methods A total of 179 patients with malig-nant tumor who underwent chemotherapy and diagnosed as CIPN were randomly divided into the control group ( n=90 ) and the study group ( n=89) .The control group received intravenous infusion with calcium gluconate 10 ml and 25%magnesium sulfate 10 ml added in 5%glucose solution;and besides the above treatment,the study group were additionally administrated withα-lipo-ic acid 600 mg added in 0.9%sodium chloride,all patients were treated for 24 days,and the nerve conducting velocity ( NCV) of median nerve and common peroneal nerve before and after treatment in the 2 groups were observed and compared,the pain degree before and after treatment were evaluated by visual analysis score ( VAS) ,and then the therapeutic effect and adverse reactions of the 2 groups were also evaluated.Results The NCV of median nerve and common peroneal nerve were both improved compared with those before the treatment in the 2 groups (P<0.05,P<0.01),but the study group showed a more significant improvement (P<0.05);VAS scores after treatment statistically decreased than that before the treatment in the study group (P<0.05),but there had no difference in VAS scores before and after treatment in the control group ( P>0.05) .After treating for 30 days,the effective rate of the study group [95.51%(85/89)] was higher than that of the control group[83.33%(75/90)](P<0.05);there had no difference in adverse drug reaction rate between the 2 groups (12.36% vs 8.89%,P>0.05),and no severe ad-verse reactions occurred in all patients.Conclusion Lipoic acid combined with calcium gluconate and magnesium sulfate can speed up the NCV of sensory nerve and motor nerve in CIPN patients,and improve the clinical symptoms and signs with synergis-tic effect and medication safety,and it is worthy of application in clinic.
