CAJ | 학술논문

目的：采用改良的血栓栓塞法建立家兔脑血栓模型，并引入CT技术等对模型进行观察与评价。方法将12只家兔随机分为伪手术组和建模组两组，导管自家兔颈外动脉逆行至颈内动脉，伪手术组注入生理盐水，建模组借助导丝注入经过体外处理的线状长血栓；术前与术后行CAT检查对照，并于术后各时间点观察行为障碍评分及头颅NCCT测量CT值进行对照。结果建模组手术前后相比较，术后4 h CTA显示建模组6例均成功置入自颈内动脉中段至大脑中动脉的血栓子；术后对动物进行行为学评分及颅脑NCCT 检查，两组比较差异均有统计学意义（P＜0．05）。结论该模型简便易行，血栓位置稳定，血栓成分与临床类似，对动物损伤相对较小，重复性好，是一种较为理想的医学实验动物脑血栓模型。
목적：채용개량적혈전전새법건립가토뇌혈전모형，병인입CT기술등대모형진행관찰여평개。방법장12지가토수궤분위위수술조화건모조량조，도관자가토경외동맥역행지경내동맥，위수술조주입생리염수，건모조차조도사주입경과체외처리적선상장혈전；술전여술후행CAT검사대조，병우술후각시간점관찰행위장애평분급두로NCCT측량CT치진행대조。결과건모조수술전후상비교，술후4 h CTA현시건모조6례균성공치입자경내동맥중단지대뇌중동맥적혈전자；술후대동물진행행위학평분급로뇌NCCT 검사，량조비교차이균유통계학의의（P＜0．05）。결론해모형간편역행，혈전위치은정，혈전성분여림상유사，대동물손상상대교소，중복성호，시일충교위이상적의학실험동물뇌혈전모형。
Objective To establish the rabbit cerebral thrombosis model by the improved thromboembolism method ,and to introduce the CT technology for observing and evaluating this model .Methods 12 rabbits were ran‐domly divided into the sham operation group and the model group .The catheter was retrogradely inserted from the external carotid artery to internal carotid artery .The sham operation group was injected by normal saline;the model group was injected by linear long thrombosis with the help of guiding wire .The CTA contrastive examinations was performed before and after operation;the scores of behavior disorder were observed at various time points after opera‐tion and the cranial NCCT measurements were contrasted .Results In the comparison between before and after oper‐ation in the model group ,CTA at postoperative 4 h displayed that 6 cases were succeeded in placing the thrombosis from the middle section of internal carotid artery to middle cerebral artery ;the behavior score and craniocerebral NC‐CT examination were performed after operation ,the differences between the two groups were statistically significant (P<0 .05) .Conclusion The model is simple ,easy to operate ,has the stable thrombosis location ,the thrombus con‐stituents are similar to clinic ,the animal injury is relatively small ,the repeatability is good ,w hich is an ideal cerebral thrombosis model of medical experimental animal .