实用癌症杂志
實用癌癥雜誌
실용암증잡지
The Practical Journal of Cancer
2015年
8期
1224-1226
,共3页
胃癌%输血%辅助化疗%生存%免疫抑制
胃癌%輸血%輔助化療%生存%免疫抑製
위암%수혈%보조화료%생존%면역억제
Gastric cancer%Blood transfusion%Adjuvant chemotherapy%Survive%Immunosuppression
目的 探讨围术期输血对胃癌根治术患者预后及免疫的影响. 方法 回顾性分析60例胃癌手术患者临床资料. 按照有无输血记录分为A组29例(48%)患者接受输血,B组31例(52%)没有接受输血. 所有患者均服用抗癌药物(丝裂霉素C和替加氟脲嘧啶). 对临床预后因素,包括输血进行多因素分析. 对淋巴细胞亚群进行测定,探讨输血的免疫抑制效果. 结果 A组5年生存率为48.8%,B组为66.9%(P<0.01). COX多元回归分析结果显示,当患者接受抗癌药物治疗后,围手术期输血是影响胃癌患者手术后生存的显著因素. 然而,CD4 +/CD8 +在手术后3个月,输血组显著低于非输血组. 结论 围术期输血患者的CD4 +/CD8 +显著低于非输血患者,能够引起免疫抑制.
目的 探討圍術期輸血對胃癌根治術患者預後及免疫的影響. 方法 迴顧性分析60例胃癌手術患者臨床資料. 按照有無輸血記錄分為A組29例(48%)患者接受輸血,B組31例(52%)沒有接受輸血. 所有患者均服用抗癌藥物(絲裂黴素C和替加氟脲嘧啶). 對臨床預後因素,包括輸血進行多因素分析. 對淋巴細胞亞群進行測定,探討輸血的免疫抑製效果. 結果 A組5年生存率為48.8%,B組為66.9%(P<0.01). COX多元迴歸分析結果顯示,噹患者接受抗癌藥物治療後,圍手術期輸血是影響胃癌患者手術後生存的顯著因素. 然而,CD4 +/CD8 +在手術後3箇月,輸血組顯著低于非輸血組. 結論 圍術期輸血患者的CD4 +/CD8 +顯著低于非輸血患者,能夠引起免疫抑製.
목적 탐토위술기수혈대위암근치술환자예후급면역적영향. 방법 회고성분석60례위암수술환자림상자료. 안조유무수혈기록분위A조29례(48%)환자접수수혈,B조31례(52%)몰유접수수혈. 소유환자균복용항암약물(사렬매소C화체가불뇨밀정). 대림상예후인소,포괄수혈진행다인소분석. 대림파세포아군진행측정,탐토수혈적면역억제효과. 결과 A조5년생존솔위48.8%,B조위66.9%(P<0.01). COX다원회귀분석결과현시,당환자접수항암약물치료후,위수술기수혈시영향위암환자수술후생존적현저인소. 연이,CD4 +/CD8 +재수술후3개월,수혈조현저저우비수혈조. 결론 위술기수혈환자적CD4 +/CD8 +현저저우비수혈환자,능구인기면역억제.
Objective To investigate the impact of perioperative blood transfusion on prognosis and immunosuppression of patients with gastric cancer.Methods Clinical data of 60 cases of gastric cancer patient were retrospectively analyzed.The pa-tients were divided into 2 groups according to whether received the blood transfusion.29 patients in group A ( 48%) received blood transfusions,31 patients in group B(52%) did not receive the blood transfusion.All patients received anti-cancer drugs ( mitomycin C and tegafur-uracil) .Clinical prognostic factors,including blood transfusion received multivariate analysis.Lympho-cyte subsets were determined to explore the effect of suppressing the immune transfusion.Results 5-year survival rates in group A and group B were 48.8%and 66.9%(P<0.01).COX multivariate regression analysis showed that when patients were receiv-ing anticancer drugs treatment,perioperative blood transfusion was significant factors affecting survival of patients after surgery. However,CD4 +/CD8 +ratio 3 months after surgery in group A was significantly lower than that of group B.Conclusion Periop-erative CD4 +/CD8 +in blood transfusion patients is significantly lower than that of non-transfusion patients,it can cause immuno-suppression.
