CAJ | 학술논문

目的：观察比较血液透析的不同通量不同速度模式，对透析效果的影响。方法按析因设计，通量因素设置高低两个水平，速度因素设置普通血液透析（HD）、缓慢连续透析（SCD）、更缓慢连续透析（MSCD）等3个水平，观测低血压发生情况，进行血液生化指标检测，并比较其中部分指标的清除变化情况。结果血压（收缩压）的比较，以 HD 模式最差（平均值较低，出现低血事件次数较多）；Na 等6项血液生化指标，高通量＋低速方式更接近正常值；血中 AGEs 指标，低速方式下下降特别明显，下降变化率竟达60．9％，而 HD 方式仅为2．1％；此外，严重心、脑血管事件，也是高通量低速模式发生较少。结论高通量和低速度透析模式，各方面的指标都较其它模式为优，建议临床上优先选择。
목적：관찰비교혈액투석적불동통량불동속도모식，대투석효과적영향。방법안석인설계，통량인소설치고저량개수평，속도인소설치보통혈액투석（HD）、완만련속투석（SCD）、경완만련속투석（MSCD）등3개수평，관측저혈압발생정황，진행혈액생화지표검측，병비교기중부분지표적청제변화정황。결과혈압（수축압）적비교，이 HD 모식최차（평균치교저，출현저혈사건차수교다）；Na 등6항혈액생화지표，고통량＋저속방식경접근정상치；혈중 AGEs 지표，저속방식하하강특별명현，하강변화솔경체60．9％，이 HD 방식부위2．1％；차외，엄중심、뇌혈관사건，야시고통량저속모식발생교소。결론고통량화저속도투석모식，각방면적지표도교기타모식위우，건의림상상우선선택。
Objective To compare the effects of different dialysis flux and speed of the hemodialysis on dialysis.Methods Factorial design was applied concerning dialysis flux and speed.The factor of dialysis flux was set at high and low levels,and the factor of dialysis speed was set at HD,SCD and MSCD modes.Then the incidence of hypotension and related blood biochemical indexes were monitored. The changes of indexes were compared.Results The blood pressure (systolic pressure)was the worst at HD mode.The six blood bio-chemical indexes including Na were closer to normal value at high dialysis flux and low speed modes.The index of AGEs declined markedly at low speed mode,which was 60.9% compared with only 2.1% at HD mode.In addition,the occurrence of severe cardiovas-cular and cerebrovascular events was less at high dialysis flux and low speed modes.Conclusion High dialysis flux and low speed modes were optimal,which was suggested as clinical priorities.