CAJ | 학술논문

目的探讨术前血清炎症标志物CRP、SAA和IL-6水平改变在结肠癌患者病情评估中的临床意义. 方法收集结肠癌患者85例(观察组) ,健康人80例(对照组) ,比较2组患者血清CRP、SAA和IL-6水平. 观察组患者术后,根据肿瘤分期(Ⅰ、Ⅱ、Ⅲ、Ⅳ期4组)和肿瘤大小(直径≤5 cm和>5 cm组)进行分组,分别比较各组患者术前检测的血清CRP、SAA和IL-6水平. 结果与对照组比较,观察组血清CRP、SAA和IL-6水平显著升高,差异有统计学意义,P<0.05. 与Ⅰ、Ⅱ期患者比较,Ⅲ、Ⅳ期患者血清CRP、SAA和IL-6水平显著升高,差异有统计学意义,P<0.05;与直径≤5 cm组比较,>5 cm组血清CRP、SAA和IL-6水平显著升高,差异有统计学意义,P<0.05. 结论结肠癌患者血清炎性标志物显著升高,且其炎症指标血清CRP、SAA和IL-6水平与肿瘤的分期和大小呈一定的正相关性,可以作为结肠癌患者病情严重程度的评估指标.
목적 탐토술전혈청염증표지물CRP、SAA화IL-6수평개변재결장암환자병정평고중적림상의의. 방법 수집결장암환자85례(관찰조) ,건강인80례(대조조) ,비교2조환자혈청CRP、SAA화IL-6수평. 관찰조환자술후,근거종류분기(Ⅰ、Ⅱ、Ⅲ、Ⅳ기4조)화종류대소(직경≤5 cm화>5 cm조)진행분조,분별비교각조환자술전검측적혈청CRP、SAA화IL-6수평. 결과 여대조조비교,관찰조혈청CRP、SAA화IL-6수평현저승고,차이유통계학의의,P<0.05. 여Ⅰ、Ⅱ기환자비교,Ⅲ、Ⅳ기환자혈청CRP、SAA화IL-6수평현저승고,차이유통계학의의,P<0.05;여직경≤5 cm조비교,>5 cm조혈청CRP、SAA화IL-6수평현저승고,차이유통계학의의,P<0.05. 결론 결장암환자혈청염성표지물현저승고,차기염증지표혈청CRP、SAA화IL-6수평여종류적분기화대소정일정적정상관성,가이작위결장암환자병정엄중정도적평고지표.
Objective To study the significance of preoperative detection of inflammatory markers CRP,SAA and IL-6 in the assessment of the severity of patients with colon cancer.Methods 85 cases of colon cancer patients were the observation group,80 cases of healthy patients were the control group,the serum CRP,SAA and IL-6 levels were compared between the 2 groups.The observation group was divided into 4 groups(Ⅰ、Ⅱ、Ⅲ、Ⅳgroup) according to the tumor stage after surgery and 2 groupsaccording to the tumor diameter ( d≤5 cm and d>5 cm) ,then serum CRP,SAA and IL-6 levels were compared.Results Compared with control group,serum CRP,SAA and IL-6 levels of the observation group increased significantly,the difference was statistically significant,P<0.05;compared with stageⅠ,Ⅱpatients,the serum CRP,SAA and IL-6 levels of stage Ⅲ and Ⅳ pa-tients significant raised,the difference was statistically significant,P<0.05;Compared with the diameter d≤5 cm group,the ser-um CRP,SAA and IL-6 levels of d>5 cm group was significant raised,the difference was statistically significant,P<0.05.Con-clusion There is a significant increase of serum inflammatory markers in colon cancer patients.There is also certain positive cor-relation between the serum CRP,SAA and IL-6 levels and tumor staging,as well as the size,thus they can play a positive role in the assessment of tumor severity,it can be used as tumor severity assessment indicators.