CAJ | 학술논문

目的：研究输卵管妊娠患者血清β-hCG水平动态变化与滋养细胞侵入输卵管壁深度的关联性，为临床治疗输卵管妊娠提供参考。方法：检测110例患侧输卵管切除的输卵管壶腹部妊娠患者术前48 h和手术当天的血清β-hCG水平，术后病理检查确定滋养细胞侵入输卵管壁的深度，采用Kruskal-Wallis H检验进行统计分析。结果：36例Ⅰ期（滋养细胞侵入黏膜层）输卵管妊娠患者48 h 血清β-hCG 水平平均降低18.35％，32例Ⅱ期（侵入肌层）患者血清β-hCG水平平均升高31.95％，42例Ⅲ期（侵入浆膜层）患者血清β-hCG水平平均升高37.55％，3组间差异具有统计学意义（ P＜0.05）。Ⅰ期患者β-hCG水平降低幅度低于Ⅱ期和Ⅲ期患者升高幅度，Ⅱ期患者升高幅度低于Ⅲ期患者（ P＜0.05）。结论：输卵管妊娠患者术前48 h血清β-hCG水平变化程度与滋养细胞侵入输卵管壁深度呈正相关，其可以作为临床上滋养细胞浸润程度判断的一项参考指标。
목적：연구수란관임신환자혈청β-hCG수평동태변화여자양세포침입수란관벽심도적관련성，위림상치료수란관임신제공삼고。방법：검측110례환측수란관절제적수란관호복부임신환자술전48 h화수술당천적혈청β-hCG수평，술후병리검사학정자양세포침입수란관벽적심도，채용Kruskal-Wallis H검험진행통계분석。결과：36례Ⅰ기（자양세포침입점막층）수란관임신환자48 h 혈청β-hCG 수평평균강저18.35％，32례Ⅱ기（침입기층）환자혈청β-hCG수평평균승고31.95％，42례Ⅲ기（침입장막층）환자혈청β-hCG수평평균승고37.55％，3조간차이구유통계학의의（ P＜0.05）。Ⅰ기환자β-hCG수평강저폭도저우Ⅱ기화Ⅲ기환자승고폭도，Ⅱ기환자승고폭도저우Ⅲ기환자（ P＜0.05）。결론：수란관임신환자술전48 h혈청β-hCG수평변화정도여자양세포침입수란관벽심도정정상관，기가이작위림상상자양세포침윤정도판단적일항삼고지표。
Objective: To study the correlation between the dynamic changes of serum β-hCG and trophoblast cells invasion depth into the tubal wall in patients with tubal pregnancy in order to provide a reference for the clinical treatment of tubal pregnancy.Methods:110 patients with tubal pregnancy treated in our hospital between April 2013 and April 2014 were recruited; and their serum β-hCG concentrations 48 h and 0 h before the operations, and the results of tests of trophoblast cells invasion depth into the tubal wall were collected.The data was analyzed by H test.Results:On average, among th 36 patients of stageⅠ( invasive depth to mucous layer) , the level of serumβ-hCG 48 h before the opeprations droped to 18.35%; for stage Ⅱ( invasive depth to muscle layer) patients the level grows by 31.95%, and for patients of stageⅢ( invasive depth to serosa) the level growed by 37.55%.The difference was significant among the groups( P<0.05) .The reduced degrees of serumβ-hCG in stageⅠpatients were lower than increased degrees in stageⅡand stageⅢpatients, and the increased degrees in stageⅡpatients were lower than in stageⅢpatients( P<0.05) .Conclusion:The preoperative change degree of serumβ-hCG is positively correlated with trophoblastic invasion depth into the tubal wall in patients with tubal pregnancy.It could be used as a reference index to judge the extent of trophoblast cell infiltration in clinical practice.