CAJ | 학술논문

目的：观察非酒精性脂肪性肝病（ NAFLD）患者血清视黄醇结合蛋白4（ RBP4）水平与早发冠心病的相关性。方法：选择79例NAFLD患者，经冠状动脉造影分为早发冠心病组49例和对照组30例。患者再根据肝脏B超检查结果分为轻、中、重度脂肪肝组。所有患者均抽外周静脉血检测生化指标、RBP4和超敏C反应蛋白（ hs-CRP）水平，并行组间比较。结果：与对照组比较，早发冠心病组血清RBP4、hs-CRP、LDL-C水平均明显增加，差异有统计学意义（ P＜0.05）。与轻度脂肪肝组比较，重度脂肪肝组合并冠心病人数增加，中度和重度脂肪肝组RBP4水平增加，差异有统计学意义（ P＜0.05）。结论：对NAFLD患者，RBP4在合并早发冠心病者中增高，并与脂肪肝的严重程度相关。
목적：관찰비주정성지방성간병（ NAFLD）환자혈청시황순결합단백4（ RBP4）수평여조발관심병적상관성。방법：선택79례NAFLD환자，경관상동맥조영분위조발관심병조49례화대조조30례。환자재근거간장B초검사결과분위경、중、중도지방간조。소유환자균추외주정맥혈검측생화지표、RBP4화초민C반응단백（ hs-CRP）수평，병행조간비교。결과：여대조조비교，조발관심병조혈청RBP4、hs-CRP、LDL-C수평균명현증가，차이유통계학의의（ P＜0.05）。여경도지방간조비교，중도지방간조합병관심병인수증가，중도화중도지방간조RBP4수평증가，차이유통계학의의（ P＜0.05）。결론：대NAFLD환자，RBP4재합병조발관심병자중증고，병여지방간적엄중정도상관。
Objective: To assess the correlation of retinol-binding protein 4 ( RBP4 ) and premature coronary artery disease in patients with non-alcoholic fatty liver diseases( NAFLD) .Methods:79 patients with NAFLD were selected for the study.With the help of coronary angiography, they were divided into two groups: premature coronary artery disease group with 49 patients and control group with 30 patients.Based on results of ultrasound examinations, they were further divided into three groups: mild fatty liver group, moderate fatty liver group and severe fatty liver group.Biochemical indexes, serum levels of RBP4 and C reactive protein were measured for correlation analysis in peripheral venous blood of the 79 patients.Results:Compared to the control group, serum levels of RBP4;C reactive protein,and LDL-C in premature coronary artery disease group had significantly larger increase( P<0.05 ) .The number of patients with coronary artery disease in severe fatty liver group, and serum levels of RBP4 in severe and moderate fatty liver groups increased significantly more than in themild fatty liver group( P<0.05 ) .Conclusion: For NAFLD patients, RBP4, which increases in premature coronary artery, is closely associated with the severity of fatty liver disease.