CAJ | 학술논문

目的：通过分析女童病因不明的反复外阴阴道炎（ RVV）过敏原特点、过敏家族史和过敏相关疾病的关系，探讨女童RVV的发生与过敏的相关性。方法：采用前瞻性病例对照研究，选择病因不明的200例青春期前RVV患者为观察组，同期参加健康查体、年龄相仿的200例健康女童为对照组，两组均行过敏原血清特异性IgE测定，记录过敏相关疾病及家族史。结果：观察组过敏原阳性率以及过敏家族史、吸入过敏、食物过敏的阳性率均明显高于对照组（ P＜0.001）。观察组中有过敏家族史者sIgE阳性组远高于sIgE阴性组（ P＜0.001），合并湿疹、鼻炎、哮喘等过敏性疾病者阳性组远高于阴性组（ P＜0.001）。结论：女童RVV与过敏体质有关，虽然这种关系的确切机制还有待研究，但过敏体质可能是RVV致病和（或）发病的促进因素。
목적：통과분석녀동병인불명적반복외음음도염（ RVV）과민원특점、과민가족사화과민상관질병적관계，탐토녀동RVV적발생여과민적상관성。방법：채용전첨성병례대조연구，선택병인불명적200례청춘기전RVV환자위관찰조，동기삼가건강사체、년령상방적200례건강녀동위대조조，량조균행과민원혈청특이성IgE측정，기록과민상관질병급가족사。결과：관찰조과민원양성솔이급과민가족사、흡입과민、식물과민적양성솔균명현고우대조조（ P＜0.001）。관찰조중유과민가족사자sIgE양성조원고우sIgE음성조（ P＜0.001），합병습진、비염、효천등과민성질병자양성조원고우음성조（ P＜0.001）。결론：녀동RVV여과민체질유관，수연저충관계적학절궤제환유대연구，단과민체질가능시RVV치병화（혹）발병적촉진인소。
Objective:To investigate associations between allergy and recurrent vulvovaginitis of undetermined etiology( RVV) of girls by analyzing the characteristics of their allergens, familial history of atopy, and allergy-related diseases.Methods:After being investigated by pediatric gynecologists, 200 patients with RVV who were considered to have undetermined etiology formed the study group.The control group consisted of 200 healthy girls. Study and control groups were investigated for atopy by means of serum specific IgE.Associated allergic diseases and familial atopy histories of the subjects were recorded.Results: The rate of atopy in the study group was significantly higher than in the control group ( P <0.001 ) .Familial history of atopy, inhaled allergens, food allergies all significantly increased the chance of positive sIgE in the study group than in the controls( P<0.001) . sIgE positive patients also tended to have higher rates of familial history of atopy and allergic diseases including eczema, rhinitis, asthma, etc.( P<0.001 ) .Conclusion: Girls'RVV is associated with allergy.Although the exact mechanism( s) of this relationship remains to be investigated, allergy might be a cause and( or) contributing factor in the pathogenesis of RVV.