CAJ | 학술논문

目的：探究胃食管反流性豚鼠模型肺组织神经激肽-1受体（ NK-1R）与咳嗽反射敏感性（ CRS）之间的关系。方法：分组建模后评估豚鼠CRS，免疫组化染色检测肺组织NK-1R的表达。结果：模型组CRS增加，肺内NK-1R表达增加（108.48±25.71 vs 38.54±17.62，P＜0.05）。肉毒毒素-A注射后较模型组咳嗽次数减少（23.33±7.53 vs 51.17±10.19，P＜0.05），NK-1R表达减少（21.59±13.45 vs 108.48±25.71，P＜0.05），潜伏时间未见改变（11.76±3.29 vs 8.24±4.73，P＞0.05）。结论：胃食管反流性豚鼠气道CRS增高可能与肺组织中NK-1R表达增加有关。
목적：탐구위식관반류성돈서모형폐조직신경격태-1수체（ NK-1R）여해수반사민감성（ CRS）지간적관계。방법：분조건모후평고돈서CRS，면역조화염색검측폐조직NK-1R적표체。결과：모형조CRS증가，폐내NK-1R표체증가（108.48±25.71 vs 38.54±17.62，P＜0.05）。육독독소-A주사후교모형조해수차수감소（23.33±7.53 vs 51.17±10.19，P＜0.05），NK-1R표체감소（21.59±13.45 vs 108.48±25.71，P＜0.05），잠복시간미견개변（11.76±3.29 vs 8.24±4.73，P＞0.05）。결론：위식관반류성돈서기도CRS증고가능여폐조직중NK-1R표체증가유관。
Objective:To explore the relationships between cough reflex sensitivity and the neurokinin-1 receptor expression in lung in the gastroesophageal reflux model.Methods:We built the model and measured cough reflex sensitivity, observed neurokinin-1 receptor in lung by immunohistochemical staining.Results: The cough reflex sensitivity and the numbers of neurokinin-1 receptor-immunoreactive substances increased ( 108.48 ±25.71 vs 38.54 ±17.62, P<0.05) in the model group.Injected botulinum toxin-A into airway, the cough times dropped (23.33 ±7.53 vs 51.17 ±10.19, P<0.05) , and the number of neurokinin-1 receptor also lowered(21.59 ±13.45 vs 108.48 ±25.71, P<0.05),but the cough latency was not significantly different(11.76 ±3.29 vs 8.24 ±4.73, P>0.05) compared to the model group.Conclusion:GERD increases the cough reflex sensitivity, and neurokinin-1 receptor in lung may play an important role in it.