CAJ | 학술논문

目的：研究钟控基因 PER1、PER2在乳腺癌中的表达，明确时钟基因表达在乳腺癌中的作用。方法：取60例乳腺癌患者癌组织和癌旁组织，分别用免疫组化办法检测 PER1、PER2基因蛋白表达，与病理和临床结果进行统计学分析。结果：PER1、PER2基因在乳腺癌细胞和癌旁组织中阳性表达率有显著差异（P＜0．01）。乳腺癌 PER1蛋白表达和 ER、PR、c －erbB2表达、组织分级有显著相关性，和年龄、肿瘤大小和分期无相关性。PER2表达和 c －erbB2、组织分级有显著相关性，和年龄、ER、PR、肿瘤大小和分期无相关性。结论：钟控基因 PER1、PER2表达缺失和乳腺癌发生有关，在乳腺癌发生过程中具有重要作用。
목적：연구종공기인 PER1、PER2재유선암중적표체，명학시종기인표체재유선암중적작용。방법：취60례유선암환자암조직화암방조직，분별용면역조화판법검측 PER1、PER2기인단백표체，여병리화림상결과진행통계학분석。결과：PER1、PER2기인재유선암세포화암방조직중양성표체솔유현저차이（P＜0．01）。유선암 PER1단백표체화 ER、PR、c －erbB2표체、조직분급유현저상관성，화년령、종류대소화분기무상관성。PER2표체화 c －erbB2、조직분급유현저상관성，화년령、ER、PR、종류대소화분기무상관성。결론：종공기인 PER1、PER2표체결실화유선암발생유관，재유선암발생과정중구유중요작용。
Objective:To investigate the gene clocked PER1,PER2 expression in breast cancer and its clinical significance in breast cancer.Methods:All 60 cases of breast cancer patientswere detected by immunohistochemical methods to confirm PER1,PER2 protein gene expression inbreast cancer tissues and adjacent tissues,and pathological and clinical results were statistically analyzed.Results:Expression of PER1,PER2 gene in breast cancer cells and ad-jacent tissues were significantly different (P <0.01).PER1 protein expression in breast cancer was significantly cor-related with ER,PR,c -erbB2 expression,histological grade,not correlated with age,tumor size and stage.PER2 pro-tein expression in breast cancer was significantly correlated with c -erbB2,histological grade,not correlated with age, tumor size and stage age,ER,PR,tumor size and stage.Conclusion:Lost of clock gene PER1,PER2 expression has an important role in the development of breast cancer.