CAJ | 학술논문

目的探讨清热活血散结中药对放疗肺损伤患者肺保护作用及其对血清炎症因子水平的影响. 方法选取118例中晚期胸部恶性肿瘤患者并随机将其分为2组,对照组(58例)接受放射治疗,治疗组(60例)在对照组基础上给予清热活血散结中药. 采用ELISA法测定2组患者血清炎症因子( TNF-α,IL-1,TGF-β1、MMP-9)水平. 结果 2组放射治疗有效率比较差异无统计学意义(P>0.05);但较对照组,治疗组肺损伤发生率明显降低,生活质量提高率明显增高,差异具有统计学意义(P<0.05). 放疗前,2组氧合指数、肺损伤评分和炎症因子(TNF-α,IL-1,TGF-β1、MMP-9)水平比较差异无统计学意义(P>0.05),放疗后,全部患者上述指标均发生一定程度的改变,放疗前后差异具有统计学意义(P<0.05). 治疗后,治疗组氧合指数明显高于对照组,肺损伤评分、TNF-α,IL-1,TGF-β1和MMP-9水平明显低于对照组,2组比较具有明显差异(P<0.05). 结论清热活血散结中药在不影响放疗疗效的基础上降低肺损伤发生率,提高了肺功能,改善了生活质量,其作用机制可能与降低炎症TNF-α,IL-1,TGF-β1和MMP-9因子水平有关.
목적 탐토청열활혈산결중약대방료폐손상환자폐보호작용급기대혈청염증인자수평적영향. 방법 선취118례중만기흉부악성종류환자병수궤장기분위2조,대조조(58례)접수방사치료,치료조(60례)재대조조기출상급여청열활혈산결중약. 채용ELISA법측정2조환자혈청염증인자( TNF-α,IL-1,TGF-β1、MMP-9)수평. 결과 2조방사치료유효솔비교차이무통계학의의(P>0.05);단교대조조,치료조폐손상발생솔명현강저,생활질량제고솔명현증고,차이구유통계학의의(P<0.05). 방료전,2조양합지수、폐손상평분화염증인자(TNF-α,IL-1,TGF-β1、MMP-9)수평비교차이무통계학의의(P>0.05),방료후,전부환자상술지표균발생일정정도적개변,방료전후차이구유통계학의의(P<0.05). 치료후,치료조양합지수명현고우대조조,폐손상평분、TNF-α,IL-1,TGF-β1화MMP-9수평명현저우대조조,2조비교구유명현차이(P<0.05). 결론 청열활혈산결중약재불영향방료료효적기출상강저폐손상발생솔,제고료폐공능,개선료생활질량,기작용궤제가능여강저염증TNF-α,IL-1,TGF-β1화MMP-9인자수평유관.
Objective To study the effect of Qingre Huoxue Sanjie Chinese Medicine on lung protection and serum in-flammatory factors for radiation therapy lung injury patients.Methods 118 cases of middle-late breast malignant tumor patients were chosen and divided into two groups at random,control group (58 cases) were accepted radiation therapy,therapy group (60 cases) were given Qingre Huoxue Sanjie Chinese Medicine in control group,serum inflammatory factors ( TNF-α,IL-1,TGF-β1, MMP-9) level were by detected by ELISA.Results Radiotherapy efficient is similar between groups (P>0.05),but compared with the control group,therapy group significantly reduced lung injury incidence,living quality improving rate increased obviously (P<0.05),before radiotherapy,two groups oxygenation index,lung injury score and inflammation factors level is no significant difference (P>0.05),after radiotherapy,above indexes of all patients had certain degree change,pre-radiotherapy and post-ra-diotherapy compared with significant difference (P<0.05),After treatment,oxygenation index of therapy group was significantly higher control group,the lung injury score,TNF-α,IL-1,TGF-β1,MMP-9 levels were significantly lower than control group ( P<0.05).Conclusion Qingre Huoxue Sanjie Chinese Medicine decreases lung injury incidence,improve lung function and life quality without affecting radiotherapy curative effect,its mechanism may be related to reduce TNF-α,IL-1,TGF-β1,MMP-9 lev-els.