CAJ | 학술논문

目的：探讨非小细胞肺癌（non －small cell lung cancer，NSCLC）组织中鼠双微体基因2（murine double mimute 2，MDM2）、乳腺癌易感基因（breast cancer susceptility gene，BRCA1）和原癌基因（C －Myc）的表达及临床意义。方法：收集 NSCLC 组织标本48例和癌旁组织20例，采用免疫组化 SP 法分别检测 MDM2、BRCA1和C －Myc 的表达，分析 MDM2与临床病理指标及与 BRCA1、C －Myc 的关系。结果：NSCLC 中 MDM2、C －Myc阳性率和 BRCA1异常表达率明显高于癌旁组织（P ＜0．05）；MDM2和 C －Myc 阳性表达与 NSCLC 的分化程度、TNM分期、有无淋巴结转移密切相关（P ＜0．05），与年龄、性别无显著性相关（P ＞0．05）；BRCA1异常表达与 NSCLC 的 TNM分期、有无淋巴结转移相关（P ＜0．05），与年龄、性别、组织类型、分化程度无显著性相关（P＞0．05）。三者的表达存在显著相关性（P ＜0．05）。结论：MDM2在 NSCLC 发生和转移中可能起重要作用，通过 MDM2、BRCA1和 C －Myc 的相关分析得出三者与 NSCLC 的浸润转移密切相关，可作为 NSCLC 预后的判断指标之一。
목적：탐토비소세포폐암（non －small cell lung cancer，NSCLC）조직중서쌍미체기인2（murine double mimute 2，MDM2）、유선암역감기인（breast cancer susceptility gene，BRCA1）화원암기인（C －Myc）적표체급림상의의。방법：수집 NSCLC 조직표본48례화암방조직20례，채용면역조화 SP 법분별검측 MDM2、BRCA1화C －Myc 적표체，분석 MDM2여림상병리지표급여 BRCA1、C －Myc 적관계。결과：NSCLC 중 MDM2、C －Myc양성솔화 BRCA1이상표체솔명현고우암방조직（P ＜0．05）；MDM2화 C －Myc 양성표체여 NSCLC 적분화정도、TNM분기、유무림파결전이밀절상관（P ＜0．05），여년령、성별무현저성상관（P ＞0．05）；BRCA1이상표체여 NSCLC 적 TNM분기、유무림파결전이상관（P ＜0．05），여년령、성별、조직류형、분화정도무현저성상관（P＞0．05）。삼자적표체존재현저상관성（P ＜0．05）。결론：MDM2재 NSCLC 발생화전이중가능기중요작용，통과 MDM2、BRCA1화 C －Myc 적상관분석득출삼자여 NSCLC 적침윤전이밀절상관，가작위 NSCLC 예후적판단지표지일。
Objective:To determine the expression of MDM2,BRCA1 and C -Myc in non -small cell lung cancer (NSCLC)and their relationship.Methods:48 cases of NSCLC and 20 normal cases were detected by immunohisto-chemistry SP method,and analyze the relationship of MDM2,BRCA1 and C -Myc.Results:The abnormal expression of MDM2,BRCA1 and C -Myc in NSCLC were significantly higher than that in normal tissue(P <0.05),the positive expression of MDM2 and C -Myc was related with degree of differentiation,tumor staging of NSCLC and lymph nodemetastasis,there was no significant correlation with age and gender(P >0.05 ),the abnormal expression of BRCA1 was related with,tumor staging of NSCLC and lymph nodemetastasis,there was no significant correlation with age,gender,histologic type,degree of differentiation(P >0.05).All of their positive expressions were related with each other(P <0.05).Conclusion:The positive expression of MDM2 may play an important role in non -small cell lung cancer.MDM2,BRCA1 and C -Myc were related with the invasion and metastasis of NSCLC.Expression of MDM2,BRCA1 and C -Myc may be valuable to further understand the squamous carcinoma.