世界中西医结合杂志
世界中西醫結閤雜誌
세계중서의결합잡지
World Journal of Integrated Traditional and Western Medicine
2015年
8期
1128-1131,1142
,共5页
糖调节受损%痰湿证%Apelin 水平%相关因素分析
糖調節受損%痰濕證%Apelin 水平%相關因素分析
당조절수손%담습증%Apelin 수평%상관인소분석
Impaired Glucose Regulation%Phlegm Damp Pattern/ Syndrome%Apeline Level%Relative Factors Analysis
目的：观察糖调节受损（IGR）痰湿证、非痰湿证患者与血清 apelin 的关系，探讨 IGR 痰湿证患者血清 apelin 与体重指数（BMI）、腰臀比（WHR）、血脂、胰岛素抵抗（IR）的相关性，从而为痰湿证的辨证提供客观依据。方法对诊断为糖调节受损者选择辨为痰湿证40例、非痰湿证40例及正常健康者40例分别进行身高、体重、腰围、臀围等临床一般资料的收集整理，并检测空腹血糖、餐后2 h 血糖、空腹胰岛素、血清 apelin、血脂等生化指标，统计分析上述指标在痰湿证与非痰湿证间的差异。结果与正常组相比，糖调节受损痰湿证组、非痰湿证组血清 apelin 均明显升高（P ﹤0.05）。IGR 痰湿证组血清 apelin 水平明显高于非痰湿证组（ P ﹤0.05）。相关性分析显示：血清 apelin 与BMI、HOMA - IR、Waist、WHR、TC、TG 呈正相关（P ﹤0.05）。进一步行多元逐步回归分析，HOMA -IR、TC、TG 和 BMI 进入回归方程是血清 apelin 的独立相关因素。痰湿证组中血清 apelin 与 BMI、HO-MA - IR、TC、TG 呈正相关（P ﹤0.05），与 Waist、WHR 无相关性。结论在糖调节受损阶段患者血清apelin 水平已经升高，且与 BMI、HOMA - IR、血脂代谢异常明显正相关；糖调节受损痰湿证患者血清apelin 明显升高，高于非痰湿证患者及正常健康者。
目的：觀察糖調節受損（IGR）痰濕證、非痰濕證患者與血清 apelin 的關繫，探討 IGR 痰濕證患者血清 apelin 與體重指數（BMI）、腰臀比（WHR）、血脂、胰島素牴抗（IR）的相關性，從而為痰濕證的辨證提供客觀依據。方法對診斷為糖調節受損者選擇辨為痰濕證40例、非痰濕證40例及正常健康者40例分彆進行身高、體重、腰圍、臀圍等臨床一般資料的收集整理，併檢測空腹血糖、餐後2 h 血糖、空腹胰島素、血清 apelin、血脂等生化指標，統計分析上述指標在痰濕證與非痰濕證間的差異。結果與正常組相比，糖調節受損痰濕證組、非痰濕證組血清 apelin 均明顯升高（P ﹤0.05）。IGR 痰濕證組血清 apelin 水平明顯高于非痰濕證組（ P ﹤0.05）。相關性分析顯示：血清 apelin 與BMI、HOMA - IR、Waist、WHR、TC、TG 呈正相關（P ﹤0.05）。進一步行多元逐步迴歸分析，HOMA -IR、TC、TG 和 BMI 進入迴歸方程是血清 apelin 的獨立相關因素。痰濕證組中血清 apelin 與 BMI、HO-MA - IR、TC、TG 呈正相關（P ﹤0.05），與 Waist、WHR 無相關性。結論在糖調節受損階段患者血清apelin 水平已經升高，且與 BMI、HOMA - IR、血脂代謝異常明顯正相關；糖調節受損痰濕證患者血清apelin 明顯升高，高于非痰濕證患者及正常健康者。
목적：관찰당조절수손（IGR）담습증、비담습증환자여혈청 apelin 적관계，탐토 IGR 담습증환자혈청 apelin 여체중지수（BMI）、요둔비（WHR）、혈지、이도소저항（IR）적상관성，종이위담습증적변증제공객관의거。방법대진단위당조절수손자선택변위담습증40례、비담습증40례급정상건강자40례분별진행신고、체중、요위、둔위등림상일반자료적수집정리，병검측공복혈당、찬후2 h 혈당、공복이도소、혈청 apelin、혈지등생화지표，통계분석상술지표재담습증여비담습증간적차이。결과여정상조상비，당조절수손담습증조、비담습증조혈청 apelin 균명현승고（P ﹤0.05）。IGR 담습증조혈청 apelin 수평명현고우비담습증조（ P ﹤0.05）。상관성분석현시：혈청 apelin 여BMI、HOMA - IR、Waist、WHR、TC、TG 정정상관（P ﹤0.05）。진일보행다원축보회귀분석，HOMA -IR、TC、TG 화 BMI 진입회귀방정시혈청 apelin 적독립상관인소。담습증조중혈청 apelin 여 BMI、HO-MA - IR、TC、TG 정정상관（P ﹤0.05），여 Waist、WHR 무상관성。결론재당조절수손계단환자혈청apelin 수평이경승고，차여 BMI、HOMA - IR、혈지대사이상명현정상관；당조절수손담습증환자혈청apelin 명현승고，고우비담습증환자급정상건강자。
Objective To observe the relationship between the patients of impaired glucose regula-tion(IGR)of phlegm damp syndrome or non - phlegm damp syndrome and serum apelin and explore the cor-relation analysis on apelin with body mass index(BMI),waist - hip ratio(WHR),blood lipid and insulin re-sistance(IR)in the patients of IGR differentiated as phlegm damp pattern/ syndrome so as to provide the ob-jective evidence on the differentiation of phlegm damp pattern/ syndrome. Methods In 40 cases of IGR with phlegm damp pattern(phlegm damp group),40 cases of IGR with non - phlegm damp pattern(non - phlegm damp group)and 40 cases of normal persons(normal group),the general data such as height,body mass, waistline and hipline were collected separately. The biochemical indexes such as fasting blood glucose (FBG),blood glucose 2h after meal(PBG),fasting insulin(FINS),serum apeline and blood lipid were de-termined. The differences in the above indexes were analyzed statistically. Results Compared with the nor-mal group,serum apelin was increased apparently in the phlegm damp group and non - phlegm damp group (P ﹤ 0. 05). The serum aplelin in the phlegm damp group was higher apparently than that in the non -phlegm damp group(P ﹤ 0. 05). The correlation analysis showed:serum apelin was positively correlative with BMI,HOMA - IR,waistline,WHR,TC and TG(P ﹤ 0. 05). In further multivariant stepwise regression analy-sis,HOMA - IR,TC,TG and BMI entered regression equation and were the independent relative factors of ser-um apelin. In the phlegm damp group,serum apelin was positively correlative to BMI,HOMA - IR,TC and TG (P ﹤0. 05)and was not correlative to waistline and WHR. Conclusion In the patients of IGR,serum apelin is increased and is apparently positively correlative to the abnormality of BWI,IR and blood lipid metabolism. In the patients of IGR differentiated as damp heat pattern/ syndrome,serum apelin is apparently increased and is higher than that in the patients of non - phlegm damp pattern/ syndrome and normal persons.
