CAJ | 학술논문

目的：探讨早期强化降压治疗与高血压脑出血（ HICH）血肿、血肿周围水肿的关系。方法将50例HICH患者随机分为强化降压组（23例）及对照组（27例）。所有患者采用常规治疗，强化降压组患者加用氨氯地平10 mg／d。入院时及入院24 h后各进行一次头颅CT检查，比较两组的血肿及血肿周围水肿体积。结果入院时强化降压组及对照组SBP、血肿体积及周围水肿体积差异均无统计学意义（均P＞0．05）。与对照组比较，强化降压组24 h SBP、血肿及血肿周围水肿体积显著缩小（均P＜0．05）。 Pearson相关分析显示， SBP与血肿、血肿周围水肿体积呈正相关（ r＝0．291，P＝0．040；r＝0．312，P＝0．027）。结论早期强化降压治疗可减少血肿、血肿周围水肿体积。
목적：탐토조기강화강압치료여고혈압뇌출혈（ HICH）혈종、혈종주위수종적관계。방법장50례HICH환자수궤분위강화강압조（23례）급대조조（27례）。소유환자채용상규치료，강화강압조환자가용안록지평10 mg／d。입원시급입원24 h후각진행일차두로CT검사，비교량조적혈종급혈종주위수종체적。결과입원시강화강압조급대조조SBP、혈종체적급주위수종체적차이균무통계학의의（균P＞0．05）。여대조조비교，강화강압조24 h SBP、혈종급혈종주위수종체적현저축소（균P＜0．05）。 Pearson상관분석현시， SBP여혈종、혈종주위수종체적정정상관（ r＝0．291，P＝0．040；r＝0．312，P＝0．027）。결론조기강화강압치료가감소혈종、혈종주위수종체적。
Objective To explore the relationship between early intensively antihypertensive therapy and hematoma, perihermatomal brain edema of hypertensive intracerebral hemorrhage (HICH).Methods Fifty HICH patients were randomly divided into intensively antihypertensive therapy group ( 23 cases ) and control group ( 27 cases). All patients were given conventional treatment, and intensively antihypertensive therapy group was administrated with 10 mg amlodipine orally per day additonally.Brain CT was performed at admission and 24 h later. Volume of hematoma and perihermatomal brain edema were compared between the two groups.Results The systolic pressure, volume of hematoma and perihermatomal brain edema of intensively antihypertensive therapy group had no significant differences compared with the control group at admission (all P>0.05).Compared with control group, systolic pressure, volume of hematoma andperihermatomal brain edema of intensively antihypertensive therapy group were significantly lower at 24 h after admission ( all P<0.05 ) .Pearson correlation analysis showed a positive correlation between SBP and volume of hematoma, perihermatomal brain edema( r=0.291, P=0.040; r=0.312, P=0.027 ) .Conclusion Early intensively antihypertensive therapy can reduce the volume of hematoma and perihermatomal brain edema of HICH.