临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
Journal of Clinical Psychosomatic Diseases
2015年
5期
60-61,66
,共3页
首发抑郁症%文拉法辛缓释片%帕罗西汀%汉密顿抑郁量表%社会功能缺陷量表%副反应量表
首髮抑鬱癥%文拉法辛緩釋片%帕囉西汀%漢密頓抑鬱量錶%社會功能缺陷量錶%副反應量錶
수발억욱증%문랍법신완석편%파라서정%한밀돈억욱량표%사회공능결함량표%부반응량표
FED%V HSRT%paroxetine%HAMD%SDSS%TESS
目的：探讨文拉法辛缓释剂与帕罗西汀治疗首发抑郁症患者的临床疗效和安全性。方法将60例抑郁症患者随机分为两组，每组30例，观察组口服文拉法辛缓释剂治疗，对照组口服帕罗西汀治疗，观察6周。于治疗前后采用汉密顿抑郁量表评定临床疗效，社会功能缺陷量表评定社会功能状况，副反应量表评定不良反应。结果治疗第2周末起两组汉密顿抑郁量表、社会功能缺陷量表评分均较治疗前有显著下降（P＜0．05或0．01），治疗各时点两组评分比较差异均无显著性（P ＞0．05）；治疗6周末，观察组显效率为80．0％、总有效率为90．0％，对照组分别为70．0％、80．0％，两组比较差异无显著性（P＞0．05）。两组不良反应均较轻微，发生率比较差异无显著性（P＞0．05）。结论文拉法辛缓释剂与帕罗西汀治疗首发抑郁症起效快，疗效显著，安全性高，且能显著提高患者的社会功能与生活质量。
目的：探討文拉法辛緩釋劑與帕囉西汀治療首髮抑鬱癥患者的臨床療效和安全性。方法將60例抑鬱癥患者隨機分為兩組，每組30例，觀察組口服文拉法辛緩釋劑治療，對照組口服帕囉西汀治療，觀察6週。于治療前後採用漢密頓抑鬱量錶評定臨床療效，社會功能缺陷量錶評定社會功能狀況，副反應量錶評定不良反應。結果治療第2週末起兩組漢密頓抑鬱量錶、社會功能缺陷量錶評分均較治療前有顯著下降（P＜0．05或0．01），治療各時點兩組評分比較差異均無顯著性（P ＞0．05）；治療6週末，觀察組顯效率為80．0％、總有效率為90．0％，對照組分彆為70．0％、80．0％，兩組比較差異無顯著性（P＞0．05）。兩組不良反應均較輕微，髮生率比較差異無顯著性（P＞0．05）。結論文拉法辛緩釋劑與帕囉西汀治療首髮抑鬱癥起效快，療效顯著，安全性高，且能顯著提高患者的社會功能與生活質量。
목적：탐토문랍법신완석제여파라서정치료수발억욱증환자적림상료효화안전성。방법장60례억욱증환자수궤분위량조，매조30례，관찰조구복문랍법신완석제치료，대조조구복파라서정치료，관찰6주。우치료전후채용한밀돈억욱량표평정림상료효，사회공능결함량표평정사회공능상황，부반응량표평정불량반응。결과치료제2주말기량조한밀돈억욱량표、사회공능결함량표평분균교치료전유현저하강（P＜0．05혹0．01），치료각시점량조평분비교차이균무현저성（P ＞0．05）；치료6주말，관찰조현효솔위80．0％、총유효솔위90．0％，대조조분별위70．0％、80．0％，량조비교차이무현저성（P＞0．05）。량조불량반응균교경미，발생솔비교차이무현저성（P＞0．05）。결논문랍법신완석제여파라서정치료수발억욱증기효쾌，료효현저，안전성고，차능현저제고환자적사회공능여생활질량。
Objective To explore the efficacy and safety of venlafaxine hydrochloride sustained‐release tab‐lets (VHSRT ) and paroxetine in the treatment of first‐episode depression (FED) .Methods Sixty FED patients were randomly assigned to two groups of 30 ones each ,observation group took orally V HSRT and control did paroxetine for 6 weeks . Efficacies were assessed with the Hamilton Depression Scale (HAMD) ,social functions with the Social Disability Screening Schedule (SDSS) ,and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results Since the end of the 2nd week the HAMD and SDSS scores of both groups lowered more significantly compared with pretreatment ( P < 0 .05 or 0 .01) ,there were no significant group differences at all time‐points (P> 0 .05) ;at the end of the 6th week obvious and total effective rate were respectively 80 .0% and 90 .0% in observation and 70 .0% and 80 .0%in control group ,which showed no significant differences (P > 0 .05) .Adverse reactions of both groups were mild ,their incidences had no significant group differences (P> 0 .05) .Conclusion Both V HSRT and paroxetine take effect rapidly in the treatment of first‐episode depression ,have higher safety and better compliance ,and could notably improve patients'social function and quality of life .
