临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
Journal of Clinical Psychosomatic Diseases
2015年
5期
57-59
,共3页
周小东%付华斌%刘知源%石建喜%宁卫东%马锐
週小東%付華斌%劉知源%石建喜%寧衛東%馬銳
주소동%부화빈%류지원%석건희%저위동%마예
难治性抑郁症%米氮平%阿立哌唑%汉密顿抑郁量表%副反应量表
難治性抑鬱癥%米氮平%阿立哌唑%漢密頓抑鬱量錶%副反應量錶
난치성억욱증%미담평%아립고서%한밀돈억욱량표%부반응량표
TRD%mitrazapine%aripiprazole%HAMD%TESS
目的:探讨米氮平联合阿立哌唑治疗难治性抑郁症的临床疗效和安全性。方法将94例难治性抑郁症患者随机分为两组,观察组口服米氮平联合阿立哌唑治疗,对照组单用米氮平治疗,观察8周。采用汉密顿抑郁量表评定临床疗效,副反应量表评定不良反应。结果治疗前两组汉密顿抑郁量表总分及各因子分比较差异均无显著性(P>0.05),治疗后观察组汉密顿抑郁量表总分及各因子分均较治疗前显著下降(P<0.01),且显著低于对照组(P<0.05或0.01)。两组不良反应较轻微,患者均可耐受。结论米氮平联合阿立哌唑治疗难治性抑郁症具有增效作用,起效快,疗效显著,安全性高,显著优于单用米氮平治疗。
目的:探討米氮平聯閤阿立哌唑治療難治性抑鬱癥的臨床療效和安全性。方法將94例難治性抑鬱癥患者隨機分為兩組,觀察組口服米氮平聯閤阿立哌唑治療,對照組單用米氮平治療,觀察8週。採用漢密頓抑鬱量錶評定臨床療效,副反應量錶評定不良反應。結果治療前兩組漢密頓抑鬱量錶總分及各因子分比較差異均無顯著性(P>0.05),治療後觀察組漢密頓抑鬱量錶總分及各因子分均較治療前顯著下降(P<0.01),且顯著低于對照組(P<0.05或0.01)。兩組不良反應較輕微,患者均可耐受。結論米氮平聯閤阿立哌唑治療難治性抑鬱癥具有增效作用,起效快,療效顯著,安全性高,顯著優于單用米氮平治療。
목적:탐토미담평연합아립고서치료난치성억욱증적림상료효화안전성。방법장94례난치성억욱증환자수궤분위량조,관찰조구복미담평연합아립고서치료,대조조단용미담평치료,관찰8주。채용한밀돈억욱량표평정림상료효,부반응량표평정불량반응。결과치료전량조한밀돈억욱량표총분급각인자분비교차이균무현저성(P>0.05),치료후관찰조한밀돈억욱량표총분급각인자분균교치료전현저하강(P<0.01),차현저저우대조조(P<0.05혹0.01)。량조불량반응교경미,환자균가내수。결론미담평연합아립고서치료난치성억욱증구유증효작용,기효쾌,료효현저,안전성고,현저우우단용미담평치료。
Objective To explore the efficacy and safety of mitrazapine coupled with small‐dose aripiprazole in treatment‐resistant depression (TRD) .Methods Ninety‐four TRD patients were randomly assigned to two groups ,observation group took orally mitrazapine coupled with aripiprazole and control did single mitrazapine for 8 weeks .Efficacies were assessed with the Hamilton Depression Scale (HAMD) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results There were no significant group differences in the total and each factor score before treatment (P> 0 .05) , those lowered more significantly after treatment compared with pretreatment in observation group (P <0 .01) ,and those were significantly lower than in control group (P < 0 .05 or 0 .01) .Adverse reactions of both groups were mild and tolerant .Conclusion Mitrazapine coupled with aripiprazole has a synergism , takes effect more rapidly ,and has an evident effect and higher safety compared with single mitrazapine in treatment‐resistant depression .