CAJ | 학술논문

目的：检测肺癌患者血清脂质的变化，探讨游离脂肪酸（FFA ）对肺腺癌患者的临床意义。方法研究纳入140例肺癌患者和50例健康人作为对照组，通过改良比色法测定血清游离脂肪酸；通过ROC曲线分析血清FFA用于辅助诊断肺腺癌可行性。结果肺癌患者血清总胆固醇（TC）和高密度脂蛋白胆固醇（HDL‐C）水平要低于对照组（P＜0．05），而三酰甘油（TG）和低密度脂蛋白胆固醇（LDL‐C）水平比较差异无统计学意义（P＞0．05）；肺腺癌患者血清FFA值均要高于其他类型肺癌组和对照组（P＜0．05），而其他类型肺癌组和对照组间差异无统计学意义（ P＞0．05）；FFA与肺腺癌患者性别、肿瘤组织学分型、淋巴结转移和远处转移均没有关系；FFA用于诊断肺腺癌的曲线下面积（AUC）为0．758（95％ CI：0．650～0．866，P＜0．05），通过最佳切点值分析得到FFA的临界值为0．82 mmol／L时，其诊断的敏感性为73％，特异性为78％。结论肺腺癌患者中部分血脂水平有异于健康人，FFA或可用于肺腺癌的辅助诊断。
목적：검측폐암환자혈청지질적변화，탐토유리지방산（FFA ）대폐선암환자적림상의의。방법연구납입140례폐암환자화50례건강인작위대조조，통과개량비색법측정혈청유리지방산；통과ROC곡선분석혈청FFA용우보조진단폐선암가행성。결과폐암환자혈청총담고순（TC）화고밀도지단백담고순（HDL‐C）수평요저우대조조（P＜0．05），이삼선감유（TG）화저밀도지단백담고순（LDL‐C）수평비교차이무통계학의의（P＞0．05）；폐선암환자혈청FFA치균요고우기타류형폐암조화대조조（P＜0．05），이기타류형폐암조화대조조간차이무통계학의의（ P＞0．05）；FFA여폐선암환자성별、종류조직학분형、림파결전이화원처전이균몰유관계；FFA용우진단폐선암적곡선하면적（AUC）위0．758（95％ CI：0．650～0．866，P＜0．05），통과최가절점치분석득도FFA적림계치위0．82 mmol／L시，기진단적민감성위73％，특이성위78％。결론폐선암환자중부분혈지수평유이우건강인，FFA혹가용우폐선암적보조진단。
Objective To detect the change of the serum lipid and to investigate the clinical significance of free fatty acid (FFA) in the patients with lung adenocarcinoma .Methods 140 lung cancer patients and 50 healthy indi‐viduals as the control group were enrolled in this study .The serum FFA level was detected by the modified colorimet‐ric method;the feasibility of serum FFA in the assisted diagnosis of lung adenocarcinoma was analyzed by the receiver operating characteristic(ROC) curve .Results The serum TC and HDL‐C levels in the lung patients were lower than those in the control group(P<0 .05);while the TG and LDL‐C levels had no statistical difference between the two groups(P>0 .05);serum FFA level in the lung adenocarcinoma patients was higher than that in the control group and other types of lung cancer groups (P<0 .05) ,while which had no difference between the control group and other lung cancer groups ;FFA had no relation with the sex ,tumor histologic classification ,lymph node metastasis and dis‐tant metastasis;the area under curve(AUC) for diagnosing lung adenocarcinoma was 0 .758 (95% CI:0 .650-0 .866 , P<0 .05) .The FFA critical value obtained by the optimal cut‐off value analysis was 0 .82 mmol/L ,the sensitivity and specificity of diagnosis were 73% and 78% respectively .Conclusion Partial blood lipid levels in the patients with lung cancer are different from the healthy individuals changed ,FFA might be used in the assisted diagnosis of lung adenocarcinoma .