CAJ | 학술논문

目的：探讨乳果糖对慢性功能性便秘患者血浆胃动素（MTL）和一氧化氮（NO）水平的影响。方法选取慢性功能性便秘患者54例为观察对象，分研究组29例和对照组24例；两组均给予基础治疗，研究组：乳果糖口服液每次10 g，每天3次，治疗6周；观察两组患者血浆 MTL、NO 的变化。结果研究组：治疗前 MTL 203．71 ng／mL，治疗6周后 MTL 371．03 ng／mL，治疗前后 MTL 水平差异有统计学意义（P ＜0．05）；治疗前 NO 120．52 ng／mL，治疗后 NO 69．01 ng／mL，治疗前后 NO 下降水平差异有统计学意义（P ＜0．05）。对照组：治疗前 MTL 206．21 ng／mL，治疗后 MTL 279 ng／mL，治疗前后 MTL 水平差异有统计学意义（P ＜0．05）；治疗前 NO 123．92 ng／mL，治疗后 NO 98．75 ng／mL，治疗前后 NO 下降水平差异有统计学意义（P ＜0．05）。研究组治疗后 MTL 水平高于对照组，NO 低于对照组，MTL、NO 分别比较，差异均有统计学意义（P ＜0．05）。结论乳果糖可以改善血浆胃肠激素的分泌，促进 MTL 分泌，降低 NO 的合成。
목적：탐토유과당대만성공능성편비환자혈장위동소（MTL）화일양화담（NO）수평적영향。방법선취만성공능성편비환자54례위관찰대상，분연구조29례화대조조24례；량조균급여기출치료，연구조：유과당구복액매차10 g，매천3차，치료6주；관찰량조환자혈장 MTL、NO 적변화。결과연구조：치료전 MTL 203．71 ng／mL，치료6주후 MTL 371．03 ng／mL，치료전후 MTL 수평차이유통계학의의（P ＜0．05）；치료전 NO 120．52 ng／mL，치료후 NO 69．01 ng／mL，치료전후 NO 하강수평차이유통계학의의（P ＜0．05）。대조조：치료전 MTL 206．21 ng／mL，치료후 MTL 279 ng／mL，치료전후 MTL 수평차이유통계학의의（P ＜0．05）；치료전 NO 123．92 ng／mL，치료후 NO 98．75 ng／mL，치료전후 NO 하강수평차이유통계학의의（P ＜0．05）。연구조치료후 MTL 수평고우대조조，NO 저우대조조，MTL、NO 분별비교，차이균유통계학의의（P ＜0．05）。결론유과당가이개선혈장위장격소적분비，촉진 MTL 분비，강저 NO 적합성。
Objective To explore the effect of lactulose oral solution in the treatment of patients with chronic functional constipation and its influence on the level of MTL and NO.Methods 54 cases of patients were selected with primary glaucoma who were treated in our hospital from June 2013 to October 2014 as research objective,and they were randomly divided into research group(29 cases)and control group(25 cases)according to the number table method.All of the patients were given treatment as diet adjusting,defecating exercise and so on.The research group got extra treatment as taking lactulose oral solution 10 g,2 to 3 times per day,for 6 weeks.Results MTL in the research group before treatment was 203.71ng/mL,and it was 371.03ng/mL after treatment for 6 weeks,there was statistically significance on difference of MTL levels between before treatment and after treatment(P <0.05).NO in the research group before treatment was 120.52ng/mL,andit was 69.01ng/mL after treatment for 6 weeks,there was statistically significance on difference of NO levels between before treatment and after treatment(P <0.05).MTL in the control group before treatment was 206.21ng/mL,which was 279ng/mL after treatment for 6 weeks,there was statistically significance on difference of MTL levels between before treatment and after treatment(P <0.05).NO in the control group before treatment was 123.92ng/mL,which was 98.75ng/mL after treatment for 6 weeks,there was statistically significance on difference of NO levels between before treatment and after treatment(P <0.05 ).MTL levels in the research group after treatment was higher than that in the control group when NO levels was lower than that in the control group,the difference was statistically significant(P <0.05).Conclusion Lactulose can improve the secretion of gastrointestinal hormones in plasma such as promoting the secretion of MTL and reducing the synthesis of NO.