中国基层医药
中國基層醫藥
중국기층의약
Chinese Journal of Primary Medicine and Pharmacy
2015年
18期
2827-2829
,共3页
冠心病心衰%丹参多酚酸盐%磷酸肌酸
冠心病心衰%丹參多酚痠鹽%燐痠肌痠
관심병심쇠%단삼다분산염%린산기산
Coronary heart disease heart failure%Salvia miltiorrhiza polyphenols acid salt%Creatine phosphate
目的：观察磷酸肌酸联合丹参多酚酸盐治疗冠心病心力衰竭的临床疗效。方法114例冠心病心力衰竭患者为研究对象，采用随机数字表法分为对照组55例和研究组59例；两组均给予抗心力衰竭常规治疗，研究组在此基础上，给予磷酸肌酸钠联合丹参多酚酸盐；观察并比较两组患者的临床疗效。结果研究组总有效率为96．61％（57／59），明显高于对照组的85.45％（47／55），差异有统计学意义（χ2＝4.427，P ＝0．035）。治疗前，两组左心射血分数（LVEF）﹑左室舒张末内径（LVEDD）﹑左室收缩末内径（LVESD）和6 min 步行距离差异均无统计学意义（均 P ＞0．05）；治疗后，研究组 LVEDD 和 LVESD 值均下降，LVEF 和6 min 步行距离均升高，差异有统计学意义（P ＜0．05），研究组 LEVSD、LVEDD 低于对照组，LVEF 及6 min 步行距离高于对照组，差异均有统计学意义（均 P ＜0．05）；两组均未发现与治疗相关的并发症或副作用。结论磷酸肌酸钠联合丹参多酚酸盐能够改善患者心功能各项指标，且副作用少。
目的：觀察燐痠肌痠聯閤丹參多酚痠鹽治療冠心病心力衰竭的臨床療效。方法114例冠心病心力衰竭患者為研究對象，採用隨機數字錶法分為對照組55例和研究組59例；兩組均給予抗心力衰竭常規治療，研究組在此基礎上，給予燐痠肌痠鈉聯閤丹參多酚痠鹽；觀察併比較兩組患者的臨床療效。結果研究組總有效率為96．61％（57／59），明顯高于對照組的85.45％（47／55），差異有統計學意義（χ2＝4.427，P ＝0．035）。治療前，兩組左心射血分數（LVEF）﹑左室舒張末內徑（LVEDD）﹑左室收縮末內徑（LVESD）和6 min 步行距離差異均無統計學意義（均 P ＞0．05）；治療後，研究組 LVEDD 和 LVESD 值均下降，LVEF 和6 min 步行距離均升高，差異有統計學意義（P ＜0．05），研究組 LEVSD、LVEDD 低于對照組，LVEF 及6 min 步行距離高于對照組，差異均有統計學意義（均 P ＜0．05）；兩組均未髮現與治療相關的併髮癥或副作用。結論燐痠肌痠鈉聯閤丹參多酚痠鹽能夠改善患者心功能各項指標，且副作用少。
목적：관찰린산기산연합단삼다분산염치료관심병심력쇠갈적림상료효。방법114례관심병심력쇠갈환자위연구대상，채용수궤수자표법분위대조조55례화연구조59례；량조균급여항심력쇠갈상규치료，연구조재차기출상，급여린산기산납연합단삼다분산염；관찰병비교량조환자적림상료효。결과연구조총유효솔위96．61％（57／59），명현고우대조조적85.45％（47／55），차이유통계학의의（χ2＝4.427，P ＝0．035）。치료전，량조좌심사혈분수（LVEF）﹑좌실서장말내경（LVEDD）﹑좌실수축말내경（LVESD）화6 min 보행거리차이균무통계학의의（균 P ＞0．05）；치료후，연구조 LVEDD 화 LVESD 치균하강，LVEF 화6 min 보행거리균승고，차이유통계학의의（P ＜0．05），연구조 LEVSD、LVEDD 저우대조조，LVEF 급6 min 보행거리고우대조조，차이균유통계학의의（균 P ＜0．05）；량조균미발현여치료상관적병발증혹부작용。결론린산기산납연합단삼다분산염능구개선환자심공능각항지표，차부작용소。
Objective To explore the effect of creatine phosphate combined with salvia miltiorrhiza polyphe-nols acid salt in treatment of coronary heart disease heart failure.Methods 114 cases of patients with coronary heart disease heart failure were selected as research objectives,who were treated in our hospital from August 2012 to August 2014.And they were randomly divided into control group(55 cases)and research group(59 cases)according to the number table method.Routine therapy of heart failure were given in both groups and the research group were added creatine phosphate combined with salvia miltiorrhiza polyphenols acid salt.The clinical efficacy of two groups of patients were observed and compared.Results The total effective rate in research group was 96.61%(57 /59), significantly higher than 85.45%(47 /55)in control group,the difference was statistically significant(χ2 =4.427, P =0.035).Before treatment,the left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter (LVEDD),left ventricular end systolic diameter(LVESD)and 6min walking distance between two groups had no sig-nificant difference(P >0.05).After treatment,the LVEDD and LVESD of research group were decreased and LVEF and 6 minutes walking distance of two groups were increased,the difference was statistically significant(P <0.05), the LVEDD and LVESD of research group were lower than that of the control group and LVEF and 6 minutes walking distance were higher than that of control group,the difference was statistically significant(P <0.05).No complications or side effects related to the treatment were found in both groups.Conclusion On the basis of routine therapy of heart failure,the effect of creatine phosphate sodium combined with salvia miltiorrhiza polyphenols acid salt in treat-ment of coronary heart disease heart failure can improve cardiac function of the patients with the indicators,and the clinical effect is obvious,and side effects is rarely observed.
