CAJ | 학술논문

目的：探讨脑梗死患者血清 S‐100β蛋白水平与脑梗死严重程度及脑损伤时间变化趋势的关系。方法对31例重度梗死患者，26例中度梗死患者，28例轻度梗死患者于发病后24 h 、第3 d 、第7 d 和第10 d 采用双抗体夹心酶联免疫吸附试验检测血清 S‐100β水平，对24名健康志愿者（对照组）于入组时检查血清 S‐100β水平，对检测结果进行对比分析。结果重度梗死组各时点血清 S‐100β蛋白水平显著高于其他3组（P＜0．01），中度梗死组各时点血清 S‐100β蛋白水平显著高于轻度梗死组及对照组（P＜0．01），轻度梗死组各时点血清 S‐100β蛋白水平显著高于对照组（P＜0．01）。3组患者3 d 内血清 S‐100β蛋白水平持续升高，3 d 后持续降低。结论脑梗死患者血清 S‐100β蛋白水平明显升高，可作为评定脑梗死患者病情变化及严重程度的生化指标。
목적：탐토뇌경사환자혈청 S‐100β단백수평여뇌경사엄중정도급뇌손상시간변화추세적관계。방법대31례중도경사환자，26례중도경사환자，28례경도경사환자우발병후24 h 、제3 d 、제7 d 화제10 d 채용쌍항체협심매련면역흡부시험검측혈청 S‐100β수평，대24명건강지원자（대조조）우입조시검사혈청 S‐100β수평，대검측결과진행대비분석。결과중도경사조각시점혈청 S‐100β단백수평현저고우기타3조（P＜0．01），중도경사조각시점혈청 S‐100β단백수평현저고우경도경사조급대조조（P＜0．01），경도경사조각시점혈청 S‐100β단백수평현저고우대조조（P＜0．01）。3조환자3 d 내혈청 S‐100β단백수평지속승고，3 d 후지속강저。결론뇌경사환자혈청 S‐100β단백수평명현승고，가작위평정뇌경사환자병정변화급엄중정도적생화지표。
Objective To explore the relationship among serum S‐100β protein levels ,cerebral infarction severity and time variation tendency of brain injuries in cerebral infarction patients .Methods Serum S‐100β protein levels were detected in the 24th hour ,3rd ,7th and 10th day after onset in 31 severe ,26 moderate and 28 mild cerebral infarction patients and at enrolment in 24 health volunteers (control group) with double antibody sandwich enzyme linked immunosorbent assay ,detection results contrastively analyzed . Results Serum S‐100β protein levels at each time‐point were significantly higher in severe than those in other 3 groups (P< 0 .01) ,so were those in moderate than in mild and control group (P< 0 .01) ,so were those in mild than in control group (P< 0 .01) .Serum S‐100β protein levels of 3 patient groups heightened continuously within 3 days and lowered continuously after 3 days .Conclusion Serum S‐100β protein levels of cerebral infarction patients heighten notably ,which could be used as a biochemical indicator evaluating patient's condition changes and severity of cerebral infarction patients .