CAJ | 학술논문

目的：探讨精神分裂症患者糖代谢异常发生状况及其相关影响因素。方法对152例首发精神分裂症患者治疗过程中的糖代谢指标进行监测，随访24个月，统计患者治疗第1个月、3个月、12个月及24个月时糖代谢异常发生状况，并分析其影响因素。结果本组患者随访24个月时糖代谢异常发生率为36．18％，其中空腹血糖损害为17．11％、糖耐量减退为10．53％、糖尿病为8．55％；糖代谢异常发生率随着服药时间的延长呈现逐渐增加趋势；Logistic 回归分析显示，高龄、肥胖及病程均是发生糖代谢异常的危险因素（P＜0．05）。结论精神分裂症患者可出现糖代谢异常症状，且糖代谢异常发生率随着服药时间的延长呈现逐渐增加趋势，其发生可能与患者的年龄、病程、体质量有关。
목적：탐토정신분렬증환자당대사이상발생상황급기상관영향인소。방법대152례수발정신분렬증환자치료과정중적당대사지표진행감측，수방24개월，통계환자치료제1개월、3개월、12개월급24개월시당대사이상발생상황，병분석기영향인소。결과본조환자수방24개월시당대사이상발생솔위36．18％，기중공복혈당손해위17．11％、당내량감퇴위10．53％、당뇨병위8．55％；당대사이상발생솔수착복약시간적연장정현축점증가추세；Logistic 회귀분석현시，고령、비반급병정균시발생당대사이상적위험인소（P＜0．05）。결론정신분렬증환자가출현당대사이상증상，차당대사이상발생솔수착복약시간적연장정현축점증가추세，기발생가능여환자적년령、병정、체질량유관。
Objective To explore the development and related influencing factors of abnormal glucose me‐tabolism in schizophrenia patients .Methods Glycometabolic indexes during treatment were detected in 152 first‐episode schizophrenics ,followed up for 24 months ,developments of abnormal glucose metabolism added up in the 1st ,3rd ,12th and 24th month of treatment ,and influencing factors analyzed .Results The incidence of abnormal glucose metabolism was 36 .18% in the 24th month of follow‐up ,in which impaired fasting glucose 17 .11% ,impaired glucose tolerance 10 .53% and diabetes 8 .55% ;the incidence of abnor‐mal glucose metabolism increased gradually along with the prolongation of medication time ;Logistic re‐gression analysis showed that advanced age ,obesity and course of disease were risk factors of abnormal glucose metabolism (P< 0 .05) .Conclusion Schizophrenia patients could present abnormal glucose me‐tabolism symptoms ,the incidence of abnormal glucose metabolism increases gradually along with the pro‐longation of medication time ,and the development of abnormal glucose metabolism could be related to age , course of disease and body mass .