CAJ | 학술논문

目的：评价不同剂量垂体后叶素在腹腔镜下子宫肌瘤剔除术中的止血作用和安全性。方法：选择择期行腹腔镜子宫肌瘤剔除术患者90例，采用随机数字表法将其分为三组（每组30例），对照组（C 组）：子宫肌瘤周围肌层注射缩宫素20 U；P1组：垂体后叶素6 U 子宫肌层注射；P2组：垂体后叶素12 U 子宫肌层注射。观察三组患者的手术情况、术中并发症及术后恢复情况，比较三组的临床疗效。结果：与 C 组相比，P1和 P2组手术时间明显缩短，术中出血量明显减少，差异有统计学意义（P ﹤0.05）。C 组、P1和 P2组术中心血管反应发生率分别为6.67％，46.67％和96.67％。与 C 组比较，P1组、P2组心血管反应发生率明显增高，差异有统计学意义（P ﹤0.01，校正后αˊ=0.0167），与 P1组比较，P2组心血管反应发生率明显升高，差异有统计学意义（P ﹤0.01）。三组术后均未见严重并发症。结论：腹腔镜子宫肌瘤剔除术患者，子宫肌瘤周围肌层注射小剂量垂体后叶素，可减少术中出血量，缩短手术时间，并发症少。
목적：평개불동제량수체후협소재복강경하자궁기류척제술중적지혈작용화안전성。방법：선택택기행복강경자궁기류척제술환자90례，채용수궤수자표법장기분위삼조（매조30례），대조조（C 조）：자궁기류주위기층주사축궁소20 U；P1조：수체후협소6 U 자궁기층주사；P2조：수체후협소12 U 자궁기층주사。관찰삼조환자적수술정황、술중병발증급술후회복정황，비교삼조적림상료효。결과：여 C 조상비，P1화 P2조수술시간명현축단，술중출혈량명현감소，차이유통계학의의（P ﹤0.05）。C 조、P1화 P2조술중심혈관반응발생솔분별위6.67％，46.67％화96.67％。여 C 조비교，P1조、P2조심혈관반응발생솔명현증고，차이유통계학의의（P ﹤0.01，교정후αˊ=0.0167），여 P1조비교，P2조심혈관반응발생솔명현승고，차이유통계학의의（P ﹤0.01）。삼조술후균미견엄중병발증。결론：복강경자궁기류척제술환자，자궁기류주위기층주사소제량수체후협소，가감소술중출혈량，축단수술시간，병발증소。
Objective:To evaluate the efficiency and safety of different doses pituitrin in patients undergoing laparoscopic hysteromyomectomy. Methods:Using the method of random number table,ninety patients who scheduled for elective laparoscop-ic myomectomy under general anesthesia,were divided into three groups(n = 30 each):control group(group C)and different doses pituitrin groups(group P1 and group P2). Group P1 was given myometrium injection with pituitrin 6 U,group P2 was giv-en myometrium injection with pituitrin 12 U,and group C was given oxytocin 20 U. To observe the operation situation,intraop-erative complications and postoperative recovery of three groups,and then compare the clinical efficacy of three groups. Re-sults:The operation time of group P1 and P2 was significantly shorter as compared with the group C,the intraoperative blood losswas less than that of the group C( P ﹤ 0 . 0 5 ). The incidences of cardiovascular responses were 6 . 6 7 % ,4 6 . 6 7 % and 96. 67% in group C,P1 and P2 respectively. The incidence of cardiovascular responses in group P1 and group P2 was signifi-cantly higher as compared with group C(P ﹤ 0. 01,correction αˊ= 0. 0167). The incidence of cardiovascular responses was sig-nificantly higher in groups P2 than in group P1(P ﹤ 0. 01). There were no serious complications in three groups postoperative. Conclusion:Small dosage pituitrin can effectively reduce the intraoperative blood loss and shorten the operation time with few complications in patients undergoing laparoscopic hysteromyomectomy.