中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
Chinese Journal of Woman and Child Health Research
2015年
4期
751-754
,共4页
徐道仙%王丽琴%陈飞琴%赵琰琰%郑士坚
徐道仙%王麗琴%陳飛琴%趙琰琰%鄭士堅
서도선%왕려금%진비금%조염염%정사견
硫酸镁%硝苯地平%妊娠期高血压疾病%血小板活性物质%抗氧化能力%血液流变学
硫痠鎂%硝苯地平%妊娠期高血壓疾病%血小闆活性物質%抗氧化能力%血液流變學
류산미%초분지평%임신기고혈압질병%혈소판활성물질%항양화능력%혈액류변학
Magnesium Sulfate%Nifedipine%pregnancy induced hypertension ( PIH )%platelet active substances%antioxidant capacity%blood rheology
目的 探索硫酸镁联合硝苯地平用于妊娠期高血压疾病( PIH)治疗时对患者血小板活性物质、抗氧化能力及血液流变学的影响. 方法 收集2013年7月至2014年7月经乐清市妇幼保健院确诊并接受治疗的130例PIH患者进行研究,按照就诊顺序被随机分作两组,各65例. 对照组为单纯采用硫酸镁治疗,观察组则采用硫酸镁联合硝苯地平进行治疗,对患者治疗前后的血小板活性物质、抗氧化能力及血液流变学各项指标进行检测和比较分析. 结果 经治疗后观察组孕妇的血小板聚集率(PAgT)、血小板α颗粒膜糖蛋白(CD62P)、血小板溶酶体膜糖蛋白(CD63)和血小板表面膜糖蛋白Ⅱb/Ⅲa(GPⅡb/Ⅲa)与对照组比较均显著降低,差异均有统计学意义(t值分别为7.885、8.560、8.944、9.139,均P<0.05);经治疗后观察组孕妇的总抗氧化能力( TAC)、超氧化物歧化酶( SOD)水平与对照组比较均显著升高,丙二醛( MDA)及脂质过氧化物( LOP)水平均显著降低,差异均有统计学意义(t值分别为6.877、7.467、6.899、7.310,均P<0.05);治疗后观察组的血流变学全血黏度高切、全血黏度低切、血浆黏度、红细胞压积指标与对照组比较均显著降低,差异均有统计学意义(t值分别为6.833、6.640、7.202、6.630,均P<0.05);观察组产后出血、产后子痫、胎盘早剥、早产、新生儿窒息及围产儿死亡发生率较对照组均显著降低( t值分别为8.434、8.822、9.732、8.709、7.322、6.563,均P<0.05). 结论 硫酸镁联合硝苯地平用于PIH治疗效果显著,能够有效改善患者的血小板活性物质、抗氧化能力及血液流变学性,值得临床借鉴和应用.
目的 探索硫痠鎂聯閤硝苯地平用于妊娠期高血壓疾病( PIH)治療時對患者血小闆活性物質、抗氧化能力及血液流變學的影響. 方法 收集2013年7月至2014年7月經樂清市婦幼保健院確診併接受治療的130例PIH患者進行研究,按照就診順序被隨機分作兩組,各65例. 對照組為單純採用硫痠鎂治療,觀察組則採用硫痠鎂聯閤硝苯地平進行治療,對患者治療前後的血小闆活性物質、抗氧化能力及血液流變學各項指標進行檢測和比較分析. 結果 經治療後觀察組孕婦的血小闆聚集率(PAgT)、血小闆α顆粒膜糖蛋白(CD62P)、血小闆溶酶體膜糖蛋白(CD63)和血小闆錶麵膜糖蛋白Ⅱb/Ⅲa(GPⅡb/Ⅲa)與對照組比較均顯著降低,差異均有統計學意義(t值分彆為7.885、8.560、8.944、9.139,均P<0.05);經治療後觀察組孕婦的總抗氧化能力( TAC)、超氧化物歧化酶( SOD)水平與對照組比較均顯著升高,丙二醛( MDA)及脂質過氧化物( LOP)水平均顯著降低,差異均有統計學意義(t值分彆為6.877、7.467、6.899、7.310,均P<0.05);治療後觀察組的血流變學全血黏度高切、全血黏度低切、血漿黏度、紅細胞壓積指標與對照組比較均顯著降低,差異均有統計學意義(t值分彆為6.833、6.640、7.202、6.630,均P<0.05);觀察組產後齣血、產後子癇、胎盤早剝、早產、新生兒窒息及圍產兒死亡髮生率較對照組均顯著降低( t值分彆為8.434、8.822、9.732、8.709、7.322、6.563,均P<0.05). 結論 硫痠鎂聯閤硝苯地平用于PIH治療效果顯著,能夠有效改善患者的血小闆活性物質、抗氧化能力及血液流變學性,值得臨床藉鑒和應用.
목적 탐색류산미연합초분지평용우임신기고혈압질병( PIH)치료시대환자혈소판활성물질、항양화능력급혈액류변학적영향. 방법 수집2013년7월지2014년7월경악청시부유보건원학진병접수치료적130례PIH환자진행연구,안조취진순서피수궤분작량조,각65례. 대조조위단순채용류산미치료,관찰조칙채용류산미연합초분지평진행치료,대환자치료전후적혈소판활성물질、항양화능력급혈액류변학각항지표진행검측화비교분석. 결과 경치료후관찰조잉부적혈소판취집솔(PAgT)、혈소판α과립막당단백(CD62P)、혈소판용매체막당단백(CD63)화혈소판표면막당단백Ⅱb/Ⅲa(GPⅡb/Ⅲa)여대조조비교균현저강저,차이균유통계학의의(t치분별위7.885、8.560、8.944、9.139,균P<0.05);경치료후관찰조잉부적총항양화능력( TAC)、초양화물기화매( SOD)수평여대조조비교균현저승고,병이철( MDA)급지질과양화물( LOP)수평균현저강저,차이균유통계학의의(t치분별위6.877、7.467、6.899、7.310,균P<0.05);치료후관찰조적혈류변학전혈점도고절、전혈점도저절、혈장점도、홍세포압적지표여대조조비교균현저강저,차이균유통계학의의(t치분별위6.833、6.640、7.202、6.630,균P<0.05);관찰조산후출혈、산후자간、태반조박、조산、신생인질식급위산인사망발생솔교대조조균현저강저( t치분별위8.434、8.822、9.732、8.709、7.322、6.563,균P<0.05). 결론 류산미연합초분지평용우PIH치료효과현저,능구유효개선환자적혈소판활성물질、항양화능력급혈액류변학성,치득림상차감화응용.
Objective To explore the influence of Magnesium Sulfate combined with Nifedipine on platelet active substances, antioxidant capacity and blood rheology of patients with pregnancy induced hypertension ( PIH) .Methods From July 2013 to July 2014 130 cases of PIH diagnosed and treated in Yueqing Maternal and Child Health Hospital were collected, and they were divided into two groups with 65 cases in each according to the order of treatment.The control group was given Magnesium Sulfate treatment only, while the observation group was given Magnesium Sulfate combined with Nifedipine treatment. The platelet active substances, antioxidant ability and hemorheologic indexes before and after treatment were observed and compared.Results After treatment, PAgT, CD62P, CD63 and GPⅡb/Ⅲa of the observation group decreased significantly compared with those of the control group, and the differences were significant ( t value was 7.885, 8.560, 8.944 and 9.139, respectively, all P<0.05).TAC and SOD levels of the observation group after treatment were significantly increased but MDA and LOP levels decreased significantly compared with the control group, and the differences were significant (t value was 6.877,7.467,6.899 and 7.310, respectively, all P <0.05).After treatment, the blood rheology indexes including whole blood viscosity (in low shear rate and in high shear rate), plasma viscosity and hct were decreased in the observation group, and the differences were significant (t value was 6.833, 6.640, 7.202 and 6.630, respectively, all P<0.05).The incidences of postpartum hemorrhage, postpartum eclampsia, placental abruption, preterm delivery, asphyxia and perinatal mortality of the observation group were significantly lower than the control group (t value was 8.434, 8.822, 9.732, 8.709, 7.322 and 6.563, respectively, all P<0.05).Conclusion Magnesium Sulfate combined with Nifedipine for PIH has significant effect, and it can effectively improve platelet active substances, antioxidant capacity and blood rheology.It is worthy of clinical reference and application.
