CAJ | 학술논문

目的：探讨原发性肺癌患者血清中 sEndoglin 的表达水平及其临床意义。方法应用 ELISA 测定101例原发性肺癌患者、80例肺部良性疾病患者和50例健康对照者血清中 sEndoglin 水平。结果原发性肺癌组、肺部良性疾病组、健康对照组血清中 sEndoglin 水平分别是8．1、3．7、3．4μg ／L 。原发性肺癌组 sEndoglin 表达水平高于肺部良性疾病组和健康对照组（均 P＜0．05）。 sEndoglin 的水平与组织学分级、临床分期、肿瘤大小和是否转移有关（均 P＜0．05），与性别、年龄和组织学类型无关。结论血清 sEndoglin 在原发性肺癌中高表达，可鉴别肺部良恶性疾病，其表达水平有助于组织学分级、临床分期、肿瘤大小和淋巴结转移的判断。
목적：탐토원발성폐암환자혈청중 sEndoglin 적표체수평급기림상의의。방법응용 ELISA 측정101례원발성폐암환자、80례폐부량성질병환자화50례건강대조자혈청중 sEndoglin 수평。결과원발성폐암조、폐부량성질병조、건강대조조혈청중 sEndoglin 수평분별시8．1、3．7、3．4μg ／L 。원발성폐암조 sEndoglin 표체수평고우폐부량성질병조화건강대조조（균 P＜0．05）。 sEndoglin 적수평여조직학분급、림상분기、종류대소화시부전이유관（균 P＜0．05），여성별、년령화조직학류형무관。결론혈청 sEndoglin 재원발성폐암중고표체，가감별폐부량악성질병，기표체수평유조우조직학분급、림상분기、종류대소화림파결전이적판단。
Objective To analyze the expression level of serum soluble Endoglin in primary lung carcinoma and its clinical significance .Methods The level of serum soluble Endoglin was detected by ELISA in 50 health controls , 80 patients with benign lung disease and 101 patients with primary lung carcinoma .Results The serum level of solu‐ble Endoglin in the primary lung carcinoma group ,the benign lung disease group and the health control group were 8 .1 ,3 .7 ,3 .4 μg /L respectively ,the primary lung carcinoma group was higher than the benign lung disease group and the health control group(P< 0 .05) .Soluble Endoglin expression level was positively correlated with the histological grade ,clinical stage ,tumor size and metastasis(P < 0 .05) ,but had no relation with sex ,age and histological type . Conclusion The serum soluble Endoglin is highly expressed in primary lung carcinoma and can differentiate benign from malignant lung diseases ,its expression level is conducive to judgment of histological grade ,clinical stage ,tumor size and lymph node metastasis .