CAJ | 학술논문

目的：探讨蜂胶总黄酮滴丸治疗慢性稳定性心绞痛（气虚血瘀证）疗效和安全性。方法选择符合慢性稳定性心绞痛诊断，并且辨证为气虚血瘀证患者64例，采用随机、双盲法分为试验组和对照组。试验组48例服用蜂胶总黄酮滴丸，3次／d ，1袋／次；对照组16例服用蜂胶总黄酮滴丸模拟剂，3次／d ，1袋／次。试验为期3个月，分别观察2组的临床疗效及其安全性。结果运动平板试验中，试验组患者治疗12周后运动完成时间、最大运动心率、运动耐量较治疗前均明显升高，有统计学意义（ P＜0.05）；试验组患者运动完成时间明显高于对照组，有统计学意义（ P＜0.05）。在缓解心绞痛方面，蜂胶总黄酮滴丸显效率为16.67％，总有效率为45.83％；中医症状疗效方面，试验组患者中医症状疗效总有效率75.00％，对照组总有效率25.00％。2组之间总有效率、有效率比较有统计学意义（ P＜0.01，P＜0.05）。西雅图量表调查中，试验组患者治疗后心绞痛稳定状态、治疗满意程度、疾病认识程度积分较治疗前均升高，有统计学意义（ P＜0.05，P＜0.01）；试验组患者治疗满意程度积分明显高于对照组，有统计学意义（ P＜0.05）。结论蜂胶总黄酮滴丸治疗气虚血瘀型慢性稳定性心绞痛疗效明显，安全性高，能有效改善心肌供血，缓解心绞痛，改善临床症状，提高心脏储备能力。蜂胶总黄酮滴丸能够缓解冠心患者身心症状，提高其生活质量。
목적：탐토봉효총황동적환치료만성은정성심교통（기허혈어증）료효화안전성。방법선택부합만성은정성심교통진단，병차변증위기허혈어증환자64례，채용수궤、쌍맹법분위시험조화대조조。시험조48례복용봉효총황동적환，3차／d ，1대／차；대조조16례복용봉효총황동적환모의제，3차／d ，1대／차。시험위기3개월，분별관찰2조적림상료효급기안전성。결과운동평판시험중，시험조환자치료12주후운동완성시간、최대운동심솔、운동내량교치료전균명현승고，유통계학의의（ P＜0.05）；시험조환자운동완성시간명현고우대조조，유통계학의의（ P＜0.05）。재완해심교통방면，봉효총황동적환현효솔위16.67％，총유효솔위45.83％；중의증상료효방면，시험조환자중의증상료효총유효솔75.00％，대조조총유효솔25.00％。2조지간총유효솔、유효솔비교유통계학의의（ P＜0.01，P＜0.05）。서아도량표조사중，시험조환자치료후심교통은정상태、치료만의정도、질병인식정도적분교치료전균승고，유통계학의의（ P＜0.05，P＜0.01）；시험조환자치료만의정도적분명현고우대조조，유통계학의의（ P＜0.05）。결론봉효총황동적환치료기허혈어형만성은정성심교통료효명현，안전성고，능유효개선심기공혈，완해심교통，개선림상증상，제고심장저비능력。봉효총황동적환능구완해관심환자신심증상，제고기생활질량。
Objective To study the clinical efficiency and evaluate the security of Total flavonoids of propolis(TFP) pills for the treatment of chronic stable angina (syndrome of qi deficiency and blood stasis ) by motion tablets .Methods Sixty four patients with stable angina pectoris type in CHD with the syndrome of qi deficiency and blood stasis were selected and divid-ed randomly into two groups:Treatment group ( n=48 ) treated with TFP pills;Control group ( n=16 ) treated with TFP analog agent .The trival lasted three months .Observing and comparing clinical symptoms effect changes between two groups and evaluate their security .Results Treadmill test:after treating ,total time of exercise ,the maximum HR during exercise test ,metabolic equivalent of treatment group were improved significantly than before ,with statistical difference ( P<0 .05 ) . The total time of exercise in treatment group was significantly longer than that in control group ,with statistical difference ( P<0 .05 ) .Alleviating angina pectoris:after treatments ,treatment group achieved 16 .67% obvious curative rate respec-tively ,and results effective rate of this group was 45 .83% .TCM symptoms curative effect ,symptom curative effect of TCM treatment group patients total effective rate was 75 .00% ;The control group total effective rate 25 .00% .After studying , anginal stability ,satisfaction on treatment ,and cognitive level on disease were higher than pre-treatment ,with statistical dif-ference ( P<0 .05 ,P<0 .01 );satisfaction on treatment in treatment group was higher than control group ,with statistical difference ( P<0 .05) .Conclusion Total flavonoids of propolis (TFP) pills have favorable clinical curative effect on angi-na pectoris of coronary heart disease .TFP can improve blood supply of cardiac muscle ,is effective in alleviating angina pec-toris and improving clinical symptoms ,and can enhance heart reserve ability ,raise the quality of life .