CAJ | 학술논문

目的：探讨沙美特罗替卡松吸入、氨茶碱片治疗绝经后女性缓解期慢性阻塞性肺疾病（COPD）的效果及其对白细胞介素（IL-6）、IL-17的影响。方法选择2011年6月至2014年6月在临朐县人民医院接受治疗的绝经后女性缓解期 COPD 患者120例。按照随机数字表法分为观察组和对照组各60例。其中观察组采用沙美特罗替卡松粉剂（规格50 g／250 g）吸入，每日2次，每次1吸。对照组口服氨茶碱片，每日3次，每次100 mg。对比两组治疗后的效果、深吸气量（ IC）、第一秒用力呼气量（FEV1）、用力呼气容积（FVC）、第一秒用力呼气量占用力肺活量百分率（FEV1％）等肺功能指标及IL-6、IL-17水平。结果观察组总有效率显著高于对照组（86.7％比71.7％，P＜0.05）；治疗后观察组IC、FEV1、FVC、FEV1％水平均显著高于对照组[（2.23±0.67） L比（1.97±0.56） L、（1.24±0.51） L 比（1.07±0.35） L、2.57±0.94比2.25±0.71、（47.38±0.72）％比（42.11±0.69）％，P＜0.05]，呼吸困难指数、6 min行走距离显著高于对照组[0.77±0.45比0.41±0.29、（43.28±19.31） m 比（29.23±11.25） m，P ＜0.01]；IL-6、IL-17水平显著低于对照组[（60.78±5.57） ng／L比（72.42±5.79） ng／L、（581±35） ng／L比（621±36） ng／L，P＜0.01]。结论沙美特罗替卡松吸入与氨茶碱片治疗绝经后女性缓解期COPD均呈现高效结果，但相对来说沙美特罗替卡松吸入治疗效果更佳，对呼吸困难缓解程度更好。
목적：탐토사미특라체잡송흡입、안다감편치료절경후녀성완해기만성조새성폐질병（COPD）적효과급기대백세포개소（IL-6）、IL-17적영향。방법선택2011년6월지2014년6월재림구현인민의원접수치료적절경후녀성완해기 COPD 환자120례。안조수궤수자표법분위관찰조화대조조각60례。기중관찰조채용사미특라체잡송분제（규격50 g／250 g）흡입，매일2차，매차1흡。대조조구복안다감편，매일3차，매차100 mg。대비량조치료후적효과、심흡기량（ IC）、제일초용력호기량（FEV1）、용력호기용적（FVC）、제일초용력호기량점용력폐활량백분솔（FEV1％）등폐공능지표급IL-6、IL-17수평。결과관찰조총유효솔현저고우대조조（86.7％비71.7％，P＜0.05）；치료후관찰조IC、FEV1、FVC、FEV1％수평균현저고우대조조[（2.23±0.67） L비（1.97±0.56） L、（1.24±0.51） L 비（1.07±0.35） L、2.57±0.94비2.25±0.71、（47.38±0.72）％비（42.11±0.69）％，P＜0.05]，호흡곤난지수、6 min행주거리현저고우대조조[0.77±0.45비0.41±0.29、（43.28±19.31） m 비（29.23±11.25） m，P ＜0.01]；IL-6、IL-17수평현저저우대조조[（60.78±5.57） ng／L비（72.42±5.79） ng／L、（581±35） ng／L비（621±36） ng／L，P＜0.01]。결론사미특라체잡송흡입여안다감편치료절경후녀성완해기COPD균정현고효결과，단상대래설사미특라체잡송흡입치료효과경가，대호흡곤난완해정도경호。
Objective To study the efficacy of salmeterol and fluticasone propionate inhalation and aminophylline tablets treating chronic obstructive pulmonary disease (COPD) at remission in postmenopausal female and the influence on interleukin 6 (IL-6),IL-17 levels.Methods During Jun.2011 and Jun.2014 in Weifang People′s Hospital,120 cases of postmenopausal women with COPD at remission were included. According to random number table method they were randomly divided into observation group and control group(n =60).The observation group was given salmeterol assigned powder(specifications 50 g/250 g) inhalation,1 inhalation per time,2 times per day.The control group was given oral aminophylline tablets,100 mg per time,three times per day.After treatment,the effect of deep inspiratory capacity(IC),the first second forced expiratory volume( FEV1 ) and forced expiratory volume ( FVC) ,the first second forced expiratory rate (FEV1%) and pulmonary function index and level of IL-6,IL-17 of the two groups were compared.Results The total effective rate of the observation group was higher than the control group (86.7%vs71.7%,P<0.05); IC,FEV1 ,FVC,FEV1% of the observation group after treatment were significantly higher than the control group [(2.23 ±0.67) L vs (1.97 ±0.56) L,(1.24 ±0.51) L vs (1.07 ±0.35) L,(2.57 ±0.94) vs (2.25 ±0.71),(47.38 ±0.72)% vs (42.11 ±0.69)%,P<0.05];the index of difficulty breathing, 6 min walking distance significantly higher than control group [0.77 ±0.45 vs 0.41 ±0.29,(43.28 ± 19.31)m vs (29.23 ±11.25) m,P <0.01];IL-6,IL-17 were significantly lower than the control group [(60.78 ±5.57) ng/L vs (72.42 ±5.79) ng/L,(581 ±35) ng/L vs (621 ±36) ng/L,P <0.01]. Conclusion Salmeterol and fluticasone propionate inhalation and aminophylline tablets both have high effi-cient results in the treatment of female remission of COPD ,but the relative effect of salmeterol and fluticasone propionate inhalation therapy is better,with better alleviation of the dyspnea.