CAJ | 학술논문

目的：分析稳定性冠心病患者心外膜脂肪组织（ EAT ）厚度与血浆N端脑利钠肽前体（ NT－proB－NP）水平的相关性。方法：115例因胸痛住院的患者行冠脉CTA并进一步行冠脉造影明确有无冠心病，选取冠脉CTA右心室游离壁切面测定EAT厚度。自动生化分析仪测定患者血浆NT－proBNP水平。结果：81例患者确诊为稳定性冠心病，34例患者排除冠心病。2组患者左心室射血分数（ LVEF ）均正常。稳定性冠心病患者血浆NT－proBNP水平的自然对数[ln（NT－proBNP）]明显高于无冠心病患者（P＜0．05），EAT厚度明显高于无冠心病患者（P＜0．05），两者之间呈正相关（P＜0．05）。校正相关影响因素后，ln（NT－proBNP）仍与EAT厚度呈正相关（P＜0．05）。多因素回归分析显示，EAT厚度是ln（NT－proBNP）的独立影响因素（P＜0．05）。结论：稳定性冠心病患者EAT厚度和血浆NT－proBNP水平均明显增加，两者密切相关。
목적：분석은정성관심병환자심외막지방조직（ EAT ）후도여혈장N단뇌리납태전체（ NT－proB－NP）수평적상관성。방법：115례인흉통주원적환자행관맥CTA병진일보행관맥조영명학유무관심병，선취관맥CTA우심실유리벽절면측정EAT후도。자동생화분석의측정환자혈장NT－proBNP수평。결과：81례환자학진위은정성관심병，34례환자배제관심병。2조환자좌심실사혈분수（ LVEF ）균정상。은정성관심병환자혈장NT－proBNP수평적자연대수[ln（NT－proBNP）]명현고우무관심병환자（P＜0．05），EAT후도명현고우무관심병환자（P＜0．05），량자지간정정상관（P＜0．05）。교정상관영향인소후，ln（NT－proBNP）잉여EAT후도정정상관（P＜0．05）。다인소회귀분석현시，EAT후도시ln（NT－proBNP）적독립영향인소（P＜0．05）。결론：은정성관심병환자EAT후도화혈장NT－proBNP수평균명현증가，량자밀절상관。
AIM:To analyze the relationship between epicardial adipose tissue (EAT) thickness and plasma N-terminal pro-B-type natriuretic peptide ( NT-proBNP ) level in the patients with stable coronary artery disease . METHODS:The patients with chest pain ( n=115) admitted to our hospital underwent coronary artery computer tomo-graphy and further underwent coronary angiography for confirming whether they had coronary artery disease .EAT thickness was evaluated at the right ventricular free wall imaged by coronary artery computer tomography .Plasma NT-proBNP level was examined by an automatic biochemistry analyzer .RESULTS:Eighty-one patients were confirmed to have stable coro-nary artery disease and thirty-four patients were excluded to have coronary artery disease .Left ventricular ejection fraction of these patients of 2 groups were all normal.The natural logarithm of plasma NT-proBNP level [ln(NT-proBNP)] of the patients with stable coronary artery disease was significantly higher than that of the patients without coronary artery disease (P<0.05).EAT thickness of the patients with stable coronary artery disease was also higher than that of the patients with -out coronary artery disease(P<0.05).EAT thickness was related to ln(NT-proBNP) positively (P<0.05).After adjust-ment of related impact factors , EAT thickness was still related to ln (NT-proBNP) positively (P<0.05).Multiple-factor regression analysis showed that EAT thickness was the independent influence factor on LnNT -proBNP (P<0.05).CON-CLUSION:EAT thickness and plasma NT-proBNP level are both increased significantly and is related to each other in the patients with stable coronary artery disease .