国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
International Journal of Urology and Nephrology
2015年
5期
726-730
,共5页
血液滤过%氨基酸类%粒细胞
血液濾過%氨基痠類%粒細胞
혈액려과%안기산류%립세포
Hemofiltration%Amino Acids%Granulocytes
目的 观察连续性高容量血液滤过(CHVHF)在治疗合并急性肾损伤(AKI)的多器官功能障碍综合征(MODS)患者中氨基酸水平与中性粒细胞吞噬功能的关系.方法 选取20例接受24h CHVHF治疗合并AKI的MODS患者,随机分成两组:HVHF组及HVHF+氨基酸组,观察单次治疗前后患者血清游离氨基酸水平及中性粒细胞吞噬指数的变化.结果 CHVHF治疗24h后,HVHF组中所有氨基酸浓度均降低,HVHF+氨基酸组中所有氨基酸浓度均较治疗前升高,多数氨基酸浓度较治疗前的差异具有统计学意义(P＜0.05),HVHF+氨基酸组所有必需氨基酸、谷氨酰胺、精氨酸浓度均高于HVHF组,差异具有统计学意义(P＜0.05).两组治疗后中性粒细胞吞噬指数均升高(P＜0.05),治疗前后中性粒细胞吞噬指数与谷氨酰胺、精氨酸水平成正相关(P＜0.05).结论 合并AKI的MODS患者在接受CHVHF治疗过程中,合理补充氨基酸尤其是谷氨酰胺、精氨酸,可以进一步改善其中性粒细胞吞噬功能.
目的 觀察連續性高容量血液濾過(CHVHF)在治療閤併急性腎損傷(AKI)的多器官功能障礙綜閤徵(MODS)患者中氨基痠水平與中性粒細胞吞噬功能的關繫.方法 選取20例接受24h CHVHF治療閤併AKI的MODS患者,隨機分成兩組:HVHF組及HVHF+氨基痠組,觀察單次治療前後患者血清遊離氨基痠水平及中性粒細胞吞噬指數的變化.結果 CHVHF治療24h後,HVHF組中所有氨基痠濃度均降低,HVHF+氨基痠組中所有氨基痠濃度均較治療前升高,多數氨基痠濃度較治療前的差異具有統計學意義(P＜0.05),HVHF+氨基痠組所有必需氨基痠、穀氨酰胺、精氨痠濃度均高于HVHF組,差異具有統計學意義(P＜0.05).兩組治療後中性粒細胞吞噬指數均升高(P＜0.05),治療前後中性粒細胞吞噬指數與穀氨酰胺、精氨痠水平成正相關(P＜0.05).結論 閤併AKI的MODS患者在接受CHVHF治療過程中,閤理補充氨基痠尤其是穀氨酰胺、精氨痠,可以進一步改善其中性粒細胞吞噬功能.
목적 관찰련속성고용량혈액려과(CHVHF)재치료합병급성신손상(AKI)적다기관공능장애종합정(MODS)환자중안기산수평여중성립세포탄서공능적관계.방법 선취20례접수24h CHVHF치료합병AKI적MODS환자,수궤분성량조:HVHF조급HVHF+안기산조,관찰단차치료전후환자혈청유리안기산수평급중성립세포탄서지수적변화.결과 CHVHF치료24h후,HVHF조중소유안기산농도균강저,HVHF+안기산조중소유안기산농도균교치료전승고,다수안기산농도교치료전적차이구유통계학의의(P＜0.05),HVHF+안기산조소유필수안기산、곡안선알、정안산농도균고우HVHF조,차이구유통계학의의(P＜0.05).량조치료후중성립세포탄서지수균승고(P＜0.05),치료전후중성립세포탄서지수여곡안선알、정안산수평성정상관(P＜0.05).결론 합병AKI적MODS환자재접수CHVHF치료과정중,합리보충안기산우기시곡안선알、정안산,가이진일보개선기중성립세포탄서공능.
Objectives To observe the relationship between the amino acid levels with neutrophil phagocytic function during continuous high volume hemofiltration (CHVHF) on the multiple organ dysfunction syndrome (MODS) patients company with acute kidney injury (AKI).Methods A total of 20 patients diagnosed with MODS companied with AKI,who would recept CHVHF for 24 hours,were selected in this study.They were randomly divided into HVHF group and HVHF + AA group.Serum free amino acid spectrum,phagocytosis indexes of polymorphonuclear neutrophil (PMN) were monitored before and after CHVHF.Results After CHVHF for 24 hours,the concentrations of all amino acids were decreased in HVHF group and increased in the HVHF + AA group,most of which were different statistically(P ＜0.05).The concentrations of all the essential amino acids,glutamine,arginine in HVHF + AA group were higher than those in HVHF group,the differences were statistically significant(P ＜ 0.05).The phagocytosis indexes of PMN (P ＜ 0.05) increased after the treatment in 2 groups.Before and after treatment neutrophil phagocytic index and glutamine,arginine levels were positively correlated(P ＜ 0.05).Conclusions The proper supplement of amino acids,especially,glutamine and arginine may improve the phagocytosis indexes of PMN during CHVHF on the MODS patients ccompany with AKI.
