国际泌尿系统杂志
國際泌尿繫統雜誌
국제비뇨계통잡지
International Journal of Urology and Nephrology
2015年
5期
722-725
,共4页
糖尿病肾病%Meta分析
糖尿病腎病%Meta分析
당뇨병신병%Meta분석
Diabetic Nephropathies%Meta-Analysis
目的 提高对糖尿病肾病(diabetic nephropathy,DN)临床表现的认识,为临床诊断提供依据.方法 检索1990～ 2014年发表的经肾活检证实为单纯DN的文献,汇总并分析DN患者的临床特点.结果 共检索出符合纳入标准文献16篇,累计报告糖尿病患者肾活检1860例,其中单纯DN患者790例(42.5％).在DN患者中,合并高血压的患者占36.3％～ 100％;合并糖尿病视网膜病变(diabetic retinopa-thy,DR)的患者占32.8％～90.9％;出现血尿的患者占16.7％～100％;出现蛋白尿的患者占16.7％～ 95.3％.DN患者肾病综合征(nephrotic syndrome,NS)的发生率为48.1％ ～78.4％;也有部分表现为急性肾损伤(acute kidney injury,AKI)、慢性肾衰竭(chronic renal failure,CRF)或急进性肾衰竭(rapidly progressive renal failure,RPRF).结论 DN临床表现具有多样性和不典型性,必要时需通过肾活检证实.
目的 提高對糖尿病腎病(diabetic nephropathy,DN)臨床錶現的認識,為臨床診斷提供依據.方法 檢索1990～ 2014年髮錶的經腎活檢證實為單純DN的文獻,彙總併分析DN患者的臨床特點.結果 共檢索齣符閤納入標準文獻16篇,纍計報告糖尿病患者腎活檢1860例,其中單純DN患者790例(42.5％).在DN患者中,閤併高血壓的患者佔36.3％～ 100％;閤併糖尿病視網膜病變(diabetic retinopa-thy,DR)的患者佔32.8％～90.9％;齣現血尿的患者佔16.7％～100％;齣現蛋白尿的患者佔16.7％～ 95.3％.DN患者腎病綜閤徵(nephrotic syndrome,NS)的髮生率為48.1％ ～78.4％;也有部分錶現為急性腎損傷(acute kidney injury,AKI)、慢性腎衰竭(chronic renal failure,CRF)或急進性腎衰竭(rapidly progressive renal failure,RPRF).結論 DN臨床錶現具有多樣性和不典型性,必要時需通過腎活檢證實.
목적 제고대당뇨병신병(diabetic nephropathy,DN)림상표현적인식,위림상진단제공의거.방법 검색1990～ 2014년발표적경신활검증실위단순DN적문헌,회총병분석DN환자적림상특점.결과 공검색출부합납입표준문헌16편,루계보고당뇨병환자신활검1860례,기중단순DN환자790례(42.5％).재DN환자중,합병고혈압적환자점36.3％～ 100％;합병당뇨병시망막병변(diabetic retinopa-thy,DR)적환자점32.8％～90.9％;출현혈뇨적환자점16.7％～100％;출현단백뇨적환자점16.7％～ 95.3％.DN환자신병종합정(nephrotic syndrome,NS)적발생솔위48.1％ ～78.4％;야유부분표현위급성신손상(acute kidney injury,AKI)、만성신쇠갈(chronic renal failure,CRF)혹급진성신쇠갈(rapidly progressive renal failure,RPRF).결론 DN림상표현구유다양성화불전형성,필요시수통과신활검증실.
Objectives To increase the awareness to diabetic nephropathy(DN),and to provide some evidence for diagnosis of DN.Methods Literature on biopsy-proven DN from 1,990 to 2,014 was searched.Clinical characteristics of biopsy-proven DN were analyzed.Results A total of 16 papers on clinical characteristics of biopsy-proven DN were selected and reviewed,in which 1,860 cases were analyzed,and 790(42.5％) cases were pathologically diagnosed as DN.Hypertension occurred in 36.3％ to 100％ of the biopsy-proven DN patients,while diabetic retinopathy(DR) in 32.8％ to 90.9％.16.7％ to 100％ of DN patents presented with hematuria while 16.7％ to 95.3％ of them with proteinuria.The prevalence of nephrotic syndrome(NS) in biopsy-proven DN was 48.1％ to 78.4％,and some patients presented with acute kidney injury(AKI),chronic renal failure(CRF),or rapidly progressive renal failure(RPRF).Conclusions Because of diverse and untypical clinical presentations of DN,kidney biopsy is important for the diagnosis.
