临床医药实践
臨床醫藥實踐
림상의약실천
Proceeding of Clinical Medicine
2015年
9期
645-649
,共5页
肾小球滤过率%冠心病严重程度评分%慢性肾病%全因病死率
腎小毬濾過率%冠心病嚴重程度評分%慢性腎病%全因病死率
신소구려과솔%관심병엄중정도평분%만성신병%전인병사솔
glomerular filtration rate%coronary artery disease severity score%chronic kidney disease%all - cause mortality
目的：探讨中度慢性肾病（CKD）作为有心肌缺血症状女性患者不良预后的独立预测因素的可行性。方法：连续选择269例住院接受冠脉造影的女性患者，根据其肾小球滤过率（eGFR）进行分组。采用调整基线变量的多变量回归分析研究入组患者全因病死率、心血管疾病病死率及主要不良事件的发生率。结果：阻塞性冠状动脉疾病（ CAD）患者仅占41％。在调整了CAD严重程度评分后，肾功能仍是对全因及心血管病死率的可靠独立预测因素（P ﹤0.001）。评估肾小球滤过率（eGFR），eGFR 每降低10 U，全因病死率增加13％，心血管疾病病死率增加17％，不良心血管事件的发生增加8％。结论：仅中等程度的 CKD 可作为有或无心肌缺血症状的女性患者全因及因心血管疾病死亡的独立预测因素。
目的：探討中度慢性腎病（CKD）作為有心肌缺血癥狀女性患者不良預後的獨立預測因素的可行性。方法：連續選擇269例住院接受冠脈造影的女性患者，根據其腎小毬濾過率（eGFR）進行分組。採用調整基線變量的多變量迴歸分析研究入組患者全因病死率、心血管疾病病死率及主要不良事件的髮生率。結果：阻塞性冠狀動脈疾病（ CAD）患者僅佔41％。在調整瞭CAD嚴重程度評分後，腎功能仍是對全因及心血管病死率的可靠獨立預測因素（P ﹤0.001）。評估腎小毬濾過率（eGFR），eGFR 每降低10 U，全因病死率增加13％，心血管疾病病死率增加17％，不良心血管事件的髮生增加8％。結論：僅中等程度的 CKD 可作為有或無心肌缺血癥狀的女性患者全因及因心血管疾病死亡的獨立預測因素。
목적：탐토중도만성신병（CKD）작위유심기결혈증상녀성환자불량예후적독립예측인소적가행성。방법：련속선택269례주원접수관맥조영적녀성환자，근거기신소구려과솔（eGFR）진행분조。채용조정기선변량적다변량회귀분석연구입조환자전인병사솔、심혈관질병병사솔급주요불량사건적발생솔。결과：조새성관상동맥질병（ CAD）환자부점41％。재조정료CAD엄중정도평분후，신공능잉시대전인급심혈관병사솔적가고독립예측인소（P ﹤0.001）。평고신소구려과솔（eGFR），eGFR 매강저10 U，전인병사솔증가13％，심혈관질병병사솔증가17％，불양심혈관사건적발생증가8％。결론：부중등정도적 CKD 가작위유혹무심기결혈증상적녀성환자전인급인심혈관질병사망적독립예측인소。
Objective:To investigate mild chronic kidney disease( CKD)independently predicts adverse outcomes in women with symptoms and signs of ischemia. Methods:To categorize 269 women referred for clinically indicated coronary angi-ography according to estimated glomerular filtration rate(eGFR). Time to death from all - cause and cardiovascular causes and major adverse outcomes were assessed by multivariate regression adjusted for baseline covariates. Results:Obstructive coronary artery disease(CAD)was present only in few patients(41% ). Even after adjusting for CAD severity,renal function remained a strong independent predictor of all - cause and cardiac mortality(P ﹤ 0. 001). Every 10 - unit decrease in eGFR was associ-ated with a 13% increased risk of all - cause mortality,17% increased risk of cardiovascular mortality,and 8% increased risk of adverse cardiovascular events. Conclusion:Even mild CKD is a strong independent predictor of all - cause and cardiac mor-tality in women with symptoms/ signs of ischemia.
