中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
Chinese Journal of Woman and Child Health Research
2015年
4期
893-895
,共3页
早产儿%脑白质损伤%促红细胞生成素%基因多态性
早產兒%腦白質損傷%促紅細胞生成素%基因多態性
조산인%뇌백질손상%촉홍세포생성소%기인다태성
premature infants%white matter damage ( WMD)%erythropoietin ( EPO)%gene polymorphisms
早产儿脑白质损伤( WMD)是神经系统伤残的主要原因之一. 影像学是WMD的确诊依据. 目前研究认为,促红细胞生成素( EPO)可促进早产儿脑发育并对脑损伤有保护作用. EPO脑保护的主要机制是抗凋亡、抗氧化、抗炎症、抗惊厥和促进脑血管新生等. 同时,EPO基因又存在多态性,可能与早产儿WMD的个体易感性差异相关联.
早產兒腦白質損傷( WMD)是神經繫統傷殘的主要原因之一. 影像學是WMD的確診依據. 目前研究認為,促紅細胞生成素( EPO)可促進早產兒腦髮育併對腦損傷有保護作用. EPO腦保護的主要機製是抗凋亡、抗氧化、抗炎癥、抗驚厥和促進腦血管新生等. 同時,EPO基因又存在多態性,可能與早產兒WMD的箇體易感性差異相關聯.
조산인뇌백질손상( WMD)시신경계통상잔적주요원인지일. 영상학시WMD적학진의거. 목전연구인위,촉홍세포생성소( EPO)가촉진조산인뇌발육병대뇌손상유보호작용. EPO뇌보호적주요궤제시항조망、항양화、항염증、항량궐화촉진뇌혈관신생등. 동시,EPO기인우존재다태성,가능여조산인WMD적개체역감성차이상관련.
White matter damage ( WMD) of premature infants is one of the significant causes leading to neurological disabilities, and imaging is the way to identify the disease.Up to now, researches have found that erythropoietin ( EPO) could not only improve brain development, but have protective effect on preterm neonatal brain injury.The fundamental mechanism of EPO is its ability of inhibiting apoptosis, anti-oxidation, anti-inflammatory, anti-epilepsy, and angiogenesis.Meanwhile, there are gene polymorphisms in EPO gene, which maybe relate with the individual susceptibility difference in WMD of premature infants.
