中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
Chinese Journal of Woman and Child Health Research
2015年
4期
709-711,714
,共4页
子宫内膜恶性肿瘤%子宫内膜良性病变%人附睾上皮分泌蛋白4%糖链抗原125
子宮內膜噁性腫瘤%子宮內膜良性病變%人附睪上皮分泌蛋白4%糖鏈抗原125
자궁내막악성종류%자궁내막량성병변%인부고상피분비단백4%당련항원125
endometrial malignant tumor%endometrial benign lesions%human epididymis secretory protein 4 (HE4)%carbohydrate antigen 125 ( CA125)
目的 探讨人附睾上皮分泌蛋白4(HE4)对子宫内膜癌的诊断意义,及其与糖链抗原125(CA125)联合检测对子宫内膜恶性肿瘤与子宫内膜良性病变的诊断价值. 方法 分别应用电化学发光法和双抗体夹心时间分辨免疫荧光分析法检测26例子宫内膜癌患者、28例功能失调性子宫出血患者及32例健康女性血清中的HE4和CA125水平,并进行分析. 结果 子宫内膜癌组的HE4水平明显高于功能失调性子宫出血组和健康对照组,差异均具有统计学意义( t值分别为2.463、2.471,均P<0.05);子宫内膜癌组中,单独检测HE4的灵敏度和特异度分别为46.27%和95.08%,单独检测CA125的灵敏度和特异度分别为39.91%和98.21%,二者联合检测时灵敏度和特异度分别为52.73%和95.03%,较CA125和HE4单项检测灵敏度增高,特异度较CA125略低. 结论 联合检测HE4和CA125提高了检测灵敏度,特异度降低,对子宫内膜癌具有更高的诊断价值,为联合检测HE4和CA125鉴别子宫内膜良、恶性肿瘤提供临床依据.
目的 探討人附睪上皮分泌蛋白4(HE4)對子宮內膜癌的診斷意義,及其與糖鏈抗原125(CA125)聯閤檢測對子宮內膜噁性腫瘤與子宮內膜良性病變的診斷價值. 方法 分彆應用電化學髮光法和雙抗體夾心時間分辨免疫熒光分析法檢測26例子宮內膜癌患者、28例功能失調性子宮齣血患者及32例健康女性血清中的HE4和CA125水平,併進行分析. 結果 子宮內膜癌組的HE4水平明顯高于功能失調性子宮齣血組和健康對照組,差異均具有統計學意義( t值分彆為2.463、2.471,均P<0.05);子宮內膜癌組中,單獨檢測HE4的靈敏度和特異度分彆為46.27%和95.08%,單獨檢測CA125的靈敏度和特異度分彆為39.91%和98.21%,二者聯閤檢測時靈敏度和特異度分彆為52.73%和95.03%,較CA125和HE4單項檢測靈敏度增高,特異度較CA125略低. 結論 聯閤檢測HE4和CA125提高瞭檢測靈敏度,特異度降低,對子宮內膜癌具有更高的診斷價值,為聯閤檢測HE4和CA125鑒彆子宮內膜良、噁性腫瘤提供臨床依據.
목적 탐토인부고상피분비단백4(HE4)대자궁내막암적진단의의,급기여당련항원125(CA125)연합검측대자궁내막악성종류여자궁내막량성병변적진단개치. 방법 분별응용전화학발광법화쌍항체협심시간분변면역형광분석법검측26례자궁내막암환자、28례공능실조성자궁출혈환자급32례건강녀성혈청중적HE4화CA125수평,병진행분석. 결과 자궁내막암조적HE4수평명현고우공능실조성자궁출혈조화건강대조조,차이균구유통계학의의( t치분별위2.463、2.471,균P<0.05);자궁내막암조중,단독검측HE4적령민도화특이도분별위46.27%화95.08%,단독검측CA125적령민도화특이도분별위39.91%화98.21%,이자연합검측시령민도화특이도분별위52.73%화95.03%,교CA125화HE4단항검측령민도증고,특이도교CA125략저. 결론 연합검측HE4화CA125제고료검측령민도,특이도강저,대자궁내막암구유경고적진단개치,위연합검측HE4화CA125감별자궁내막량、악성종류제공림상의거.
Objective To explore the diagnostic value of human epididymis secretory protein 4 ( HE4) in endometrial malignant tumor and to compare it with carbohydrate antigen 125 ( CA125 ) in diagnosis of endometrial malignant tumor and endometrial benign lesions. Methods Serum levels of HE4 and CA125 in 26 cases of endometrial carcinoma, 28 cases of dysfunctional uterine bleeding, and 32 cases of healthy controls were detected with electrochemiluminescence immunoassay and double antibody sandwich time-resolved immunofluorescence analysis method.Results Serum levels of HE4 among endometrial cancer patients were obviously higher than those of patients with dysfunctional uterine bleeding and healthy controls, and the differences were significant ( t value was 2.463 and 2.471, respectively, both P<0.05).In endometrial cancer group, the sensitivity and specificity of detection of HE4 were 46.27%and 95.08%, respectively, and those of CA125 were 39.91%and 98.21%, respectively.The sensitivity of joint detection (52.73%) was higher than that of HE4 and CA125, but the specificity of joint detection (95.03%) was lower than that of CA125.Conclusion Joint detection of HE4 and CA125 improves the sensitivity but reduces the specificity, which has higher diagnostic value for endometrial cancer.It provides clinical evidence for differential diagnosis of endometrial benign from malignant tumors.
