检验医学与临床
檢驗醫學與臨床
검험의학여림상
Laboratory Medicine and Clinic
2015年
18期
2669-2670,2673
,共3页
甲硝唑缓释药膜%牙周炎%临床效果
甲硝唑緩釋藥膜%牙週炎%臨床效果
갑초서완석약막%아주염%림상효과
metronidazole sustained-release membrane%periodontitis%clinical effect
目的：观察应用甲硝唑缓释药膜治疗牙周炎的临床效果。方法选取2012年7月至2014年6月南充市中心医院收诊的牙周炎患者84例，随机分为观察组和对照组。观察组42例患者，采用甲硝唑缓释药膜（山西晋新双鹤药业有限公司生产，批号：021025）治疗患者牙周炎，将药物插在牙周袋内，每2天1次，1片／次。对照组42例患者，采取碘甘油（上海运佳黄埔制药有限公司，国药准字 H31021302）治疗，每2天1次，每次20 g 。术后观察两组的治疗效果，比较两组患者在治疗前后的牙龈出血、牙龈指数和牙周袋深度的相关参数。最后统计分析复发率和不良反应。结果观察组患者牙周炎治疗的总有效率为90．48％，对照组为61．91％，观察组患者治疗总有效率明显高于对照组。通过甲硝唑缓释药膜治疗牙周炎的观察组患者在治疗前后牙龈出血、牙龈指数和牙周袋深度明显下降，而对照组的治疗效果则不明显；通过甲硝唑缓释药膜治疗牙周炎的观察组患者的不良反应患者明显低于对照组患者；观察组患者的复发率仅为4．76％，而对照组复发率为28．57％，差异有统计学意义（P＜0．05）。结论应用甲硝唑缓释药膜治疗牙周炎的临床效果良好，复发率低，建议临床推广使用。
目的：觀察應用甲硝唑緩釋藥膜治療牙週炎的臨床效果。方法選取2012年7月至2014年6月南充市中心醫院收診的牙週炎患者84例，隨機分為觀察組和對照組。觀察組42例患者，採用甲硝唑緩釋藥膜（山西晉新雙鶴藥業有限公司生產，批號：021025）治療患者牙週炎，將藥物插在牙週袋內，每2天1次，1片／次。對照組42例患者，採取碘甘油（上海運佳黃埔製藥有限公司，國藥準字 H31021302）治療，每2天1次，每次20 g 。術後觀察兩組的治療效果，比較兩組患者在治療前後的牙齦齣血、牙齦指數和牙週袋深度的相關參數。最後統計分析複髮率和不良反應。結果觀察組患者牙週炎治療的總有效率為90．48％，對照組為61．91％，觀察組患者治療總有效率明顯高于對照組。通過甲硝唑緩釋藥膜治療牙週炎的觀察組患者在治療前後牙齦齣血、牙齦指數和牙週袋深度明顯下降，而對照組的治療效果則不明顯；通過甲硝唑緩釋藥膜治療牙週炎的觀察組患者的不良反應患者明顯低于對照組患者；觀察組患者的複髮率僅為4．76％，而對照組複髮率為28．57％，差異有統計學意義（P＜0．05）。結論應用甲硝唑緩釋藥膜治療牙週炎的臨床效果良好，複髮率低，建議臨床推廣使用。
목적：관찰응용갑초서완석약막치료아주염적림상효과。방법선취2012년7월지2014년6월남충시중심의원수진적아주염환자84례，수궤분위관찰조화대조조。관찰조42례환자，채용갑초서완석약막（산서진신쌍학약업유한공사생산，비호：021025）치료환자아주염，장약물삽재아주대내，매2천1차，1편／차。대조조42례환자，채취전감유（상해운가황포제약유한공사，국약준자 H31021302）치료，매2천1차，매차20 g 。술후관찰량조적치료효과，비교량조환자재치료전후적아간출혈、아간지수화아주대심도적상관삼수。최후통계분석복발솔화불량반응。결과관찰조환자아주염치료적총유효솔위90．48％，대조조위61．91％，관찰조환자치료총유효솔명현고우대조조。통과갑초서완석약막치료아주염적관찰조환자재치료전후아간출혈、아간지수화아주대심도명현하강，이대조조적치료효과칙불명현；통과갑초서완석약막치료아주염적관찰조환자적불량반응환자명현저우대조조환자；관찰조환자적복발솔부위4．76％，이대조조복발솔위28．57％，차이유통계학의의（P＜0．05）。결론응용갑초서완석약막치료아주염적림상효과량호，복발솔저，건의림상추엄사용。
Objective To observe the application of clinical observation for metronidazole sustained release membrane in the treatment for periodontitis .Methods 84 cases of hospital patients with periodontitis were studied form July 2012 to June 2014 in my diagnosis .Randomly divided into observation group and control group .Observa‐tion group 42 cases were treated with metronidazole sustained‐release film with (Shanxi new Double‐Crane Pharma‐ceutical Co .Ltd .,batch number :021025) in the treatment of patients with periodontitis ,the drug inserted in the peri‐odontal pockets ,once every 2 days ,each time one piece .Control group of 42 patients taking iodine glycerin (Shanghai Pharmaceutical Co .Ltd .Yunjia Whampoa ,Zhunzi H31021302) treatment ,once every 2 days ,each time 20 g .Postop‐erative treatment effect was observed in both groups .Then compare the two groups of patients who were before and after treated of gingival bleeding ,gingival index and related parameters periodontal pocket depth .Finally ,statistical a‐nalysis of recurrence and adverse reactions .Results The total study group of patients with periodontitis treatment effective rate 90 .48% ,61 .91% in the control group ,patients in the observation group were significantly higher over‐all efficiency .By observing patients treated of periodontitis for sustained‐release film with metronidazole ,Gingival bleeding ,gingival index and periodontal pocket depth was significantly decreased after treatment ,while the control group ,the treatment effect is not significant .Adverse reactions observed in patients with patients through the sus‐tained‐release film with metronidazole treatment of periodontitis patients was significantly lower than the control group .Relapse rate of patients in the observation group was 4 .76% ,while the control group ,the recurrence rate was 28 .57% .The control group was significantly higher relapse rate .Conclusion Metronidazole sustained‐release mem‐brane in the treatment of periodontitis good clinical effect ,the recurrence rate is low ,the proposed clinical use .
