国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
International Journal of Laboratory Medicine
2015年
17期
2500-2501
,共2页
Rta蛋白抗体IgG%鼻咽癌%诊断
Rta蛋白抗體IgG%鼻嚥癌%診斷
Rta단백항체IgG%비인암%진단
Rta protein antibody IgG%nasopharynx cancer%diagnosis
目的：探讨EB病毒的Rta蛋白抗体IgG（Rta／IgG）在珠海地区鼻咽癌患者中的临床诊断价值。方法75例经病理检测确诊，但未经治疗的鼻咽癌患者纳入鼻咽癌组，100例体检健康者纳入健康对照组，肝癌组、胃癌组、肺癌组、淋巴瘤组、宫颈癌组各19例患者。采用酶联免疫吸附试验检测Rta／IgG、EB病毒壳抗体（VCA／IgA ）在各组被试中的表达水平，并进行比较分析。结果鼻咽癌组患者Rta／IgG阳性率明显高于肝癌组、胃癌组、肺癌组、淋巴瘤组、乳腺癌组、宫颈癌组及健康对照组，差异有统计学意义（P＜0．05）。鼻咽癌组Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期患者血清中Rta／IgG阳性率差异均无统计学意义（P＞0．05）。Rta／IgG、VCA／IgA单独检测及 VCA／IgA 联合 Rta／IgG 检测对鼻咽癌诊断的灵敏度分别为81．3％、89．3％、94．6％，特异度分别为93．0％、84．0％、80．0％。结论 Rta／IgG是鼻咽癌早期辅助诊断及筛查的可靠血清学指标，Rta／IgG的表达与鼻咽癌临床分期无关，Rta／IgG联合VCA／IgA检测提高了鼻咽癌的筛查和诊断灵敏度。
目的：探討EB病毒的Rta蛋白抗體IgG（Rta／IgG）在珠海地區鼻嚥癌患者中的臨床診斷價值。方法75例經病理檢測確診，但未經治療的鼻嚥癌患者納入鼻嚥癌組，100例體檢健康者納入健康對照組，肝癌組、胃癌組、肺癌組、淋巴瘤組、宮頸癌組各19例患者。採用酶聯免疫吸附試驗檢測Rta／IgG、EB病毒殼抗體（VCA／IgA ）在各組被試中的錶達水平，併進行比較分析。結果鼻嚥癌組患者Rta／IgG暘性率明顯高于肝癌組、胃癌組、肺癌組、淋巴瘤組、乳腺癌組、宮頸癌組及健康對照組，差異有統計學意義（P＜0．05）。鼻嚥癌組Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期患者血清中Rta／IgG暘性率差異均無統計學意義（P＞0．05）。Rta／IgG、VCA／IgA單獨檢測及 VCA／IgA 聯閤 Rta／IgG 檢測對鼻嚥癌診斷的靈敏度分彆為81．3％、89．3％、94．6％，特異度分彆為93．0％、84．0％、80．0％。結論 Rta／IgG是鼻嚥癌早期輔助診斷及篩查的可靠血清學指標，Rta／IgG的錶達與鼻嚥癌臨床分期無關，Rta／IgG聯閤VCA／IgA檢測提高瞭鼻嚥癌的篩查和診斷靈敏度。
목적：탐토EB병독적Rta단백항체IgG（Rta／IgG）재주해지구비인암환자중적림상진단개치。방법75례경병리검측학진，단미경치료적비인암환자납입비인암조，100례체검건강자납입건강대조조，간암조、위암조、폐암조、림파류조、궁경암조각19례환자。채용매련면역흡부시험검측Rta／IgG、EB병독각항체（VCA／IgA ）재각조피시중적표체수평，병진행비교분석。결과비인암조환자Rta／IgG양성솔명현고우간암조、위암조、폐암조、림파류조、유선암조、궁경암조급건강대조조，차이유통계학의의（P＜0．05）。비인암조Ⅰ기、Ⅱ기、Ⅲ기、Ⅳ기환자혈청중Rta／IgG양성솔차이균무통계학의의（P＞0．05）。Rta／IgG、VCA／IgA단독검측급 VCA／IgA 연합 Rta／IgG 검측대비인암진단적령민도분별위81．3％、89．3％、94．6％，특이도분별위93．0％、84．0％、80．0％。결론 Rta／IgG시비인암조기보조진단급사사적가고혈청학지표，Rta／IgG적표체여비인암림상분기무관，Rta／IgG연합VCA／IgA검측제고료비인암적사사화진단령민도。
Objective To evaluate the clinical value of Rta protein antibody IgG of EB virus(Rta/IgG)in the diagnosis of naso‐pharyngeal carcinoma patients in Zhuhai .Methods A total of 75 patients with nasopharyngeal cancer diagnosed by histopathologi‐cal detection without therapy were recruited into nasopharyngeal cancer group ,100 healthy persons were selected into control group ,there were 19 patients in liver cancer ,gastric cancer ,lung cancer ,lymphoma group and cervical cancer group .Rta/IgG and EB virus antibody of shell (VCA/IgA) were detected by enzyme‐linked immunosorbent assay .Results The positive rate of Rta/IgG in the nasopharyngeal cancer group was significant higher than those of liver cancer ,gastric cancer ,lung cancer ,lymphoma group and cervical cancer and control group(P<0 .05) .The positive rates of Rta/IgG in different clinical stage of nasopharyngeal cancer had no significant differences(P>0 .05) .The sensitivity rates of Rta/IgG single detection ,VCA/IgA single detection ,com‐bined detection of Rta/IgG and VCA/IgA were 81 .3% ,89 .3% ,94 .6% respectively ,while the specificity rates were 93 .0% ,84 . 0% ,80 .0% respectively .Conclusion Rta/IgG is a sensitive and specific serologic parameter for nasopharynx cancer diagnosis ,but it is not a proper maker for evaluating clinical stage of nasopharynx cancer .The combined detection of Rta/IgG and VCA/IgA could improve the diagnosis rate of nasopharyngeal carcinoma in Zhuhai .
