CAJ | 학술논문

microRNA是一组小的非编码RNA分子,它广泛存在于真核细胞生物中,许多研究表明microRNA与炎症性疾病的发生发展相关,其中包括COPD.研究发现在COPD中某些miRNA出现表达增多,某些则被发现表达下降.近年来microRNA与COPD的基因调控正成为关注热点,这也为临床治疗COPD提供了又一新方法.现就microRNA在COPD的发病机制方面的作用研究进展作一综述.
microRNA시일조소적비편마RNA분자,타엄범존재우진핵세포생물중,허다연구표명microRNA여염증성질병적발생발전상관,기중포괄COPD.연구발현재COPD중모사miRNA출현표체증다,모사칙피발현표체하강.근년래microRNA여COPD적기인조공정성위관주열점,저야위림상치료COPD제공료우일신방법.현취microRNA재COPD적발병궤제방면적작용연구진전작일종술.
MicroRNA (miRNA) is a class of small non-coding RNA molecules,which is widely present in eukaryotic cell biology,many studies have shown that the development of microRNA associated with inflammatory diseases,including chronic obstructive pulmonary disease (COPD).Several miRNA have been proved increased expression or decreased expression in patients with COPD.In this review,we summarize our current understanding of microRNA in the pathogenesis of COPD.